代书炎，男，特聘副教授，药理学/结构药理学，硕士生导师

个人简介

代书炎，男，1987年生，中南大学湘雅药学院特聘副教授，硕士生导师。吉林大学学士，中国科学院生物物研究所博士（硕博连读），中南大学湘雅医院助理研究员、博士后。近5年发表SCI论文25篇，其中第一/通讯作者（含共同）论文8篇，包括Nature Communications 1篇、Nucleic Acids Research 2篇、高被引用论文1篇、封面文章1篇（Journal of Molecular Biology）；获国家授权发明专利1项；作为副主编出版学术专著2本；主持湖南省科技厅项目、中国博士后基金项目、中南大学特聘人才科研启动项目等5项，总经费143万；作为主要完成人获湖南省医学科技奖一等奖1项。

研究方向

1. 转录因子成靶潜力挖掘及新靶分子开发；

2. 转录因子在血脑屏障稳态维持中的作用研究。

联系方式

daishuyan@csu.edu.cn

代表性论文/著作

1. Dai S., Qu L., Li J., Zhang Y., Jiang L., Wei Hu., Guo M., Chen X., Chen Y.. Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor. Nat Commun,2022;13, 6234.

2. Dai S, Qu L, Li J, Chen Y. Toward a mechanistic understanding of DNA binding by forkhead transcription factors and its perturbation by pathogenic mutations. Nucleic Acids Res. 2021;49:10235-49

3. Li J^# , Dai S^# , Chen X, Liang X, Qu L, Jiang L, et al. Mechanism of forkhead transcription factors binding to a novel palindromic DNA site. Nucleic Acids Res. 2021;49:3573-83.

4. Zhang H, Dai S*, Liang X, Li J*, Chen Y*. Mechanistic Insights into the Preference for Tandem Binding Sites in DNA Recognition by FOXM1. J Mol Biol. 2021;434:167426.

5. Dai S, Li J, Zhang H, Chen X, Guo M, Chen Z, et al. Structural Basis for DNA Recognition by FOXG1 and the Characterization of Disease-causing FOXG1 Mutations. J Mol Biol. 2020;432:6146-56.

6. Dai S, Zhou Z, Chen Z, Xu G, Chen Y. Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors. Cells. 2019;8.

7. Qu, L., Guo, M., Zhang, H., Chen, X., Wei, H., Jiang, L., Li, J., Chen, Z., Dai, S.*, and Chen, Y*. Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates. Biochemical and Biophysical Research Communications. 2022; 12;605:9-15.

8. Dai S^# , Sun C^# , Tan K, Ye S, Zhang R. Structure of thrombospondin type 3 repeats in bacterial outer membrane protein A reveals its intra-repeat disulfide bond-dependent calcium-binding capability. Cell Calcium. 2017;66:78-89.

9.《医学结构蛋白质组学》，湖南科学技术出版社，2021。（副主编）

10.《结构蛋白质组学研究在湘雅》，湖南科学技术出版社，2023。（副主编）