中南大学，湘雅药学院，副教授，博士生导师

电子邮箱：xyu226@csu.edu.cn

欢迎加入！长期招聘博士后！

个人简介

2007年和2009年分别在北京大学药学院获得本科和硕士学位，2013年于德国马尔堡大学药物生物学和生物技术研究所获得博士学位，之后依次在肯塔基大学药学院和加州大学洛杉矶分校从事博士后研究。2016年入职中南大学湘雅药学院，研究领域为微生物天然产物生物合成和生物催化研究。

研究兴趣

1. 微生物来源活性天然产物的生物合成研究

2. 微生物次级代谢产物的基因组挖掘

3. 天然产物及衍生物的生物催化研究。

主持科研项目

1. 国家自然科学基金面上项目，21877129，2019/01-2022/12，63万元，主持

2. 湖湘青年英才支持计划，2020RC3007，2020/11-2023/10，50万元，主持

3. 国家自然科学基金青年基金项目，21708049，2018/01-2020/12，25万元，主持

代表性论文

1. D. Li^#, W. Wang^#, K. Xu^#, J. Li, B. Long, Z. Li, G. Tan, and X. Yu^*, Elucidation of a Dearomatization Route in the Biosynthesis of Oxysporidinone Involving a TenA-like Cytochrome P450 Enzyme, Angewandte Chemie International Edition, 2023, 62(25), e202301976. （影响因子16.6）

2. Y. Xu^#, D. Li^#, W. Wang, K. Xu, G. Tan, J Li, S.-M. Li, and X. Yu^*, Dearomative gem-diprenylation of hydroxynaphthalenes by an engineered fungal prenyltransferase, RSC Advances, 2022, 12, 27550.

3. S. Bao, X. Zhong, Y. Wan, G. Tan, K. Xu, and X. Yu^*, Synthesis of halogenated diphenylpiperazines from L-tyrosine derivatives by biotransformation, Chemistry Letters, 2022, 51, 13-15

4. S. Bao, L. Luo, Y. Wan, K. Xu, G. Tan, J. Fan, S.-M. Li, and X. Yu^*, Regiospecific 7-O-prenylation of anthocyanins by a fungal prenyltransferase, Bioorganic Chemistry, 2021, 110, 104787.

5. Y. Xu, D. Li, G. Tan, Y. Zhang, Z. Li, K. Xu, S.-M. Li, and X. Yu^*, A single amino acid switch alters the prenyl donor specificity of a fungal aromatic prenyltransferase toward biflavonoids, Organic Letters, 2021, 23(2), 497–502.

6. R. Wheeler^#, X. Yu^#, C. Hou^#, P. Mitra, J. Chen, F. Herkules, D. N. Ivanov, O. V. Tsodikov^*, and J. Rohr^*, Discovery of a cryptic intermediate in late steps of mithramycin biosynthesis, Angewandte Chemie International Edition, 2020, 59(2): 826-832.

7. K. Xu, C. Yang, Y. Xu, D. Li, S. Bao, Z. Zou, F. Kang, G. Tan, S.-M. Li and X. Yu^*, Selective geranylation of biflavonoids by Aspergillus terreus aromatic prenyltransferase (AtaPT), Organic & Biomolecular Chemistry, 2020, 18(1): 28-31.

8. C. Yang, Y. Xu, K. Xu, G. Tan, and X. Yu^*, Preparation of new halogenated diphenyl pyrazine analogs in Escherichia coli by a mono-module fungal nonribosomal peptide synthetase from Penicillium herquei, Tetrahedron Letters, 2018, 59(32): 3084-3087.

9. X. Yu, F. Liu, Y. Zou, M. Tang, L. Hang, K. N. Houk^*, and Y. Tang^*. Biosynthesis of Strained Piperazine Alkaloids: Uncovering the Concise Pathway of Herquline A, Journal of the American Chemical Society, 2016, 138, 13529–13532.

10. X. Yu, G. Zocher, X. Xie, M. Liebhold, S. Schütz, T. Stehle, and S.-M. Li^*. Catalytic mechanism of stereospecific formation of cis-configured prenylated pyrroloindoline diketopiperazines by indole prenyltransferases, Chemistry & Biology, 2013, 20, 1492-1501.

11. S. Yin^#, X. Yu^#, Q. Wang, X. Liu^*, and S.-M. Li^*. Identification of a brevianamide F reverse prenyltransferase BrePT from Aspergillus versicolor with a broad substrate specificity towards tryptophan-containing cyclic dipeptides, Applied Microbiology and Biotechnology, 2013, 97, 1649-1660.

12. X. Yu, Y. Liu, X. Xie, X. Zheng, and S.-M. Li^*. Biochemical characterization of indole prenyltransferases: filling the last gap of prenylation positions by a 5-dimethylallyltryptophansynthase from Aspergillus clavatus, Journal of Biological Chemistry, 2012, 287, 1371-1380.

13. X. Yu, A. Yang, W. Lin, and S.-M. Li^*. Friedel–Crafts alkylation on indolocarbazoles catalyzed by two dimethylallyltryptophan synthases from Aspergillus, Tetrahedron Letters, 2012, 53, 6861-6864.

14. X. Yu and S.-M. Li^*, Prenyltransferases of the dimethylallyltryptophan synthase superfamily, Methods in Enzymology, 2012, 516, 259-278.

15. X. Yu, and S.-M. Li^*, Prenylation of flavonoids by using a dimethylallyltryptophan synthase 7-DMATS from Aspergillus fumigatus, Chembiochem, 2011, 12(15), 2280-2283.

16. X. Yu, X. Xie, and S.-M. Li^*, Substrate promiscuity of secondary metabolite enzymes: prenylation of hydroxynaphthalenes by fungal indole prenyltransferases, Applied Microbiology and Biotechnology, 2011, 92, 737-748.

17. W. Yin^#, X. Yu^#, X. Xie, and S.-M. Li^*, Preparation of pyrrolo[2,3-b]indoles carrying a ß-configured reverse C3-dimethylallyl moiety by using a recombinant prenyltransferase CdpC3PT, Organic & Biomolecular Chemistry, 2010, 8, 2430-2438.