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发布时间:2023/09/28   阅读量:


邓友超特聘副教授,19906月生,籍贯湖南省怀化市。20163月,获中南大学化学化工学院制药工程专业工学硕士,师从蒋玉仁教授;20196月,获中南大学药学专业医学博士学位,师从沈奔教授、段燕文教授及黄勇教授;20198月- 20235月,美国普渡大学药学院,从事表观遗传靶点(甲基/乙酰基转移酶)小分子抑制剂的博士后研究工作,师从黄蓉教授。曾获国家奖学金,中南大学“优秀研究生”,中南大学“优秀博士毕业生”,“优秀博士学位论文”等荣誉称号。




1. The Purdue College of Pharmacy is pleased to honor and recognize the outstanding research and scholarship generated by our faculty each month. This month we highlight Drs. Youchao Deng, Postdoc in Medicinal Chemistry and Molecular Pharmacology, and Rong Huang, Professor of Medicinal Chemistry and Molecular Pharmacology, for their recent publication, " Structure–Activity Relationship Studies of Venglustat on NTMT1 Inhibition", which can be read in the Journal of Medicinal Chemistry (January, 2023; DOI: 10.1021/acs.jmedchem.2c01854).


2. 普渡大学黄蓉团队报道α-N-末端甲基转移酶NTMT1的体内活性小分子抑制剂.


3. 普渡大学黄蓉团队报道α-N-末端甲基转移酶的小分子抑制剂.


4. 普渡大学黄蓉团队报道α-N-末端乙酰基转移酶D的新型抑制剂.


5. 中南大学湘雅国际转化医学联合研究院在抗感染新药研发上取得新进展.



1. Deng Y, Song X, Iyamu ID, et al. A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors. Acta Pharmaceutica Sinica B, 2023. (中科院一区,Top 期刊,IF 14.5)

2. Deng Y, Deng S, Ho Y H, et al. Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D[J]. Journal of Medicinal Chemistry, 2021, 64: 8263-8271. (中科院一区,Top 期刊,IF 8.06)

3. Dong G#, Deng Y#, Yasgar, A, et al. Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner[J]. Journal of Medicinal Chemistry, 2022, 65: 12334-12345. ( 中科院一区,Top 期刊, IF 8.06)

4. Deng Y, Weng X, Li Y, et al. Late-stage functionalization of platensimycin leading to multiple analogues with improved antibacterial activity in vitro and in vivo[J]. Journal of medicinal chemistry, 2019, 62: 6682-6693. (中科院一区,Top 期刊, IF 8.06)

5. Deng Y, Su M, Kang D, et al. Semisynthesis of platensimycin derivatives with antibiotic activities in mice via Suzuki–Miyaura cross-coupling reactions[J]. Journal of medicinal chemistry, 2018, 61: 11341-11348. (中科院一区,Top 期刊, IF 8.06)

6. Deng Y, Dong G, Meng Y, et al. Structure–Activity Relationship Studies of Venglustat on NTMT1 Inhibition[J]. Journal of Medicinal Chemistry, 2023, 66: 1601–1615. (中科院一区,Top 期刊, IF 8.06)

7. Deng Y, Kang D, Shi J, et al. The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin[J]. MedChemComm, 2018, 9: 789-794.(封面, JCR Q2, IF 3.6

8. Deng Y, Li Y, Wen Z, et al. Morphing Natural Product Platensimycin via Heck, Sonogashira, and One-Pot Sonogashira/Cycloaddition Reactions to Produce Antibiotics with In Vivo Activity[J]. Antibiotics, 2022, 11, 425. (JCR Q2, IF 5.2)

9. Zhou, J#, Deng Y#, et al. Comparative study of adenosine analogs as inhibitors of protein arginine methyltransferases and a Clostridioides difficile-specific DNA adenine methyltransferase[J]. ACS Chemical Biology, 2023. (JCR Q1, IF 4.6)

10. Al-Hamashi A A, Chen D, Deng Y, et al. Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5[J]. Acta Pharmaceutica Sinica B, 2020, 1: 2709-2718. (Top 期刊, IF 14.9)

11. Cao D, Yang J, Deng Y, et al. Discovery of a mammalian FASN inhibitor against xenografts of non-small cell lung cancer and melanoma[J]. Signal Transduction and Targeted Therapy, 2022, 7: 1-4. (Top 期刊, IF 38.1)

12. Dong L B, Rudolf J D, Kang D, et al. Biosynthesis of thiocarboxylic acid-containing natural products[J]. Nature communications, 2018, 9: 1-10. (Top 期刊, IF 17.6)