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博士生导师

周文虎教授
发布时间:2020/12/14   阅读量:

 

周文虎

中共党员

中南大学,湘雅药学院,教授

博士,博士生导师,系副主任/院团委副书记

邮箱:zhouwenhuyaoji@163.com;

 zhouwenhu@csu.edu.cn 

 

 

教育经历:

2013.09-2016.12

中南大学,药学院,药剂学系,博士

导师:丁劲松

2014.10-2016.09

University of Waterloo;国家公派联合培养博士

导师:Juewen Liu

2014.02-2014.09

University of Waterloo;访问博士

导师:Juewen Liu

2010.09-2013.06

中南大学,药学院,药剂学系,硕士

导师:丁劲松

2006.09-2010.06

中南大学,药学院,学士

 

 

工作经历:

2017.03-至今    中南大学    特聘教授

 

研究领域:

Ø 应用基础研究:

1. 多功能纳米载体的构建与生物医学应用;

2. 基于疾病病理机制的纳米药物设计;

3. 功能核酸(如核酸适配体、DNA酶)在疾病诊疗中的应用;

4. 新型微生物制剂(如细菌等)的开发

Ø 应用研究:基于纳米的新医疗器械研发

 

人才项目:

湖南省科技人才托举工程,年轻优秀科技人才,湖南省科协,2020

湖南省优秀青年基金,肿瘤药剂学,湖南省科技厅,2021

湖湘青年英才,湖南省科技厅,2021

 

科研成果:

Ø 科研项目:

国家自然科学基金,可突破免疫屏障的“隐形”沙门氏菌联合放疗免疫增敏用于宫颈癌的治疗研究,57主持U19031252020-2022

国家自然科学基金,基于功能核酸串联的诊疗一体化探针的构建与应用研究,25万,主持,218041442019-2021

中央高校基本科研业务费专项基金,“一体三用”的DNAzyme递送策略研究,65万,主持,2017-2018

中央高校基本科研业务费专项基金,特聘教授,120万,主持,2017-2021

硫酸羟氯喹片生物等效性预试验合作研究,横向研究,71万,主持,2017-2018

SM-1细胞活性与细胞内Procaspase-3酶原含量的相关性研究,横向研究,4.4万,主持,2017-2018

一种用于抗胰腺癌的纳米制剂开发,横向研究,20万,主持,2020-2021

一种用于抗乳腺癌的纳米制剂开发,横向研究,20万,主持,2020-2022

一种机械纳米材料的研制及其质量评价,横向研究,20万,主持,2020-2021

先必新和恩必普对缺血性脑卒中的疗效比较,横向研究,25万,主持,2021-2022

 

Ø 发明专利:

纳米配位聚合物及其制备方法和应用,ZL 201910805848.4排名第一(授权)

一种抑制活化巨噬细胞增殖的聚合物/银活性键合物及其制备和应用,ZL 201910374069.3排名第一(授权)

一种酸性环境中可降解的表面涂层及其制备方法与应用,ZL 202010675017.2排名第一(授权)

一种电荷可控的聚合物材料及其制备方法与应用,ZL 202010676053.0排名第一(授权)

Nano coordination polymer and preparation method and application thereof, US-2020-0392296-A1, 排名第一(实质审查)

用于治疗癌症的组合物及其应用,CN202011244260.5排名第一(实质审查)

包载甲氨蝶呤的铁-鞣酸配合物及其制备方法与应用,CN202010903340.0排名第一(实质审查)

 

Ø 发表论文:以第一/通讯作者身份在国际著名学术期刊Chemical Reviews, ACS Nano, Nano letters, Biomaterials, Materials Horizons, Nucleic Acids Research等累计发表SCI学术论文50余篇。

 

代表性论文

1. Yuejia Song, Yaqian Huang, Fang Zhou, Jinsong Ding*, Wenhu Zhou*, Macrophage-targeted nanomedicine for chronic diseases immunotherapy, Chinese Chemical Letters, In Press

2. Shengmei Wang, Xuanjun Liu, Shengfeng Wang, Linqi Ouyang, Hui Li, Jinsong Ding, Guiming Deng*, and Wenhu Zhou*, Imatinib co-loaded targeted realgar nanocrystal for synergistic therapy of chronic myeloid leukemia, Journal of Controlled Release, 2021, 338, 190-200

3. Yang Zeng, Haiyan Zhou, Jinsong Ding, and Wenhu Zhou*, Cell membrane inspired nano-shell enabling long-acting Glucose Oxidase for Melanoma starvation therapy via microneedles-based percutaneous delivery, Theranostics, 2021; 11:8270-8282

4. Peng Liu, Yanbin Zhou, Xinyi Shi, Yu Yuan, Ying Peng, Jinsong Ding, Yong Li*, and Wenhu Zhou*, A Cyclic Nano-reactor Achieving Enhanced Photodynamic Tumor Therapy by Reversing Multiple Resistances, J. Nanobiotechnol., 2021, 19, 149

5. Peng Liu, Ying Peng, Yanbin Zhou, Xinyi Shi, Qingnian Li, Jinsong Ding, Yang Gao,* and Wenhu Zhou*, Rapamycin as a “One-Stone-Three-Birds” Agent for Cooperatively Enhanced Phototherapies Against Metastatic Breast Cancer, ACS Appl. Mater. Interfaces, 2021, 13, 22, 25674–25684

6. Peng Liu, Xinyi Shi, Shenghui Zhong, Ying Peng, Yan Qi, Jinsong Ding, Wenhu Zhou*, Metal-phenolic networks for cancer theranostics, Biomater. Sci., 2021,9, 2825-2849

7. Shenghui Zhong, Peng Liu, Jinsong Ding* and Wenhu Zhou*, Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy, Crystals, 2021, 11(4), 321-334

8. Man Guo, Yingcai Meng, Xiaoqun Qin*, and Wenhu Zhou*, Dopamine-Grafted Hyaluronic Acid Coated Hyperbranched Poly(β-Amino Esters)/DNA Nano-Complexes for Enhanced Gene Delivery and Biosafety, Crystals, 2021, 11(4), 347-360

9. Yang Xi, Xin Xie, Ying Peng, Peng Liu, Jinsong Ding* and Wenhu Zhou*, DNAzyme-adsorbed polydopamine@MnO2 core–shell nanocomposites for enhanced photothermal therapy via the self-activated suppression of heat shock protein 70, Nanoscale, 2021, 13, 5125-5135

10. Peng Liu, Xin Xie, Miao Liu, Shuo Hu, Jinsong Ding, Wenhu Zhou*, A Smart MnO2 Doped Graphene Oxide Nanosheet for Enhanced Chemo-Photodynamic Combinatorial Therapy via Simultaneous Oxygenation and Glutathione Depletion, Acta Pharmaceutica Sinica B, 2021, 11, 823-834

11. Yihua Yang, Lina Guo, Zhe Wang, Peng Liu, Xuanjun Liu, Jinsong Ding, Wenhu Zhou*, Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization, Biomaterials, 2021, 246, 120390

12. Lina Guo, Yang Chen, Ting Wang, Yu Yuan, Yihua Yang, Xiaoli Luo, Shuo Hu, Jinsong Ding* and Wenhu Zhou*, Rational design of metal-organic frameworks to deliver methotrexate for targeted rheumatoid arthritis therapy, Journal of Controlled Release, 2021, 330, 119-131

13. Ze Mi#, Lina Guo#, Peng Liu#, Yan Qi, Zhichao Feng, Jiahao Liu, Zhenhu He, Xiao Yang, Shengnan Jiang, Jianzhen Wu, Jinsong Ding, Wenhu Zhou*, and Pengfei Rong*, Trojan Horse” Salmonella Enabling Tumor Homing of Silver Nanoparticles via Neutrophil Infiltration for Synergistic Tumor Therapy and Enhanced Biosafety, Nano letters, 2021, 21, 1, 414–423

14. Yingcai Meng, Yuan Chen, Jiaojiao Zhu, Yan Qi, Jinsong Ding, Wenhu Zhou*, Polarity Control of DNA Adsorption Enabling Surface Functionalization of CuO Nanozyme for Targeted Tumor Therapy, Materials Horizons, 2021, 8, 972-986

15. Peng Liu, Xuanjun Liu, Yan Cheng, Shenghui Zhong, Xinyi Shi, Shengfeng Wang, Jinsong Ding, Wenhu Zhou*, Core-Shell Nanosystems for Self-Activated Drug-Gene Combinations against Triple-Negative Breast Cancer, ACS Appl. Mater. Interfaces, 2020, 48, 53654-53664

16. Yunbo Nie, Dan Li, Ying Peng, Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, Metal Organic Framework Coated MnO2 Nanosheets Delivering Doxorubicin and Self-activated DNAzyme for Chemo-gene Combinatorial Treatment of Cancer, International Journal of Pharmaceutics, 2020, 585, 1195

17. Ying Peng, Peng Liu, Yingcai Meng, Jinsong Ding* and Wenhu Zhou*, Nanoscale Copper(II)-Diethyldithiocarbamate Coordination Polymer as Drug Self-delivery System for Highly Robust and Specific Cancer Therapy, Molecular Pharmaceutics, 2020, 8, 2864-2873

18. Miao Liu, Ying Peng, Yunbo Nie, Peng Liu, Shuo Hu, Jinsong Ding* and Wenhu Zhou*, Co-delivery of doxorubicin and DNAzyme using ZnO@polydopamine core-shell nanocomposites for chemo/gene/photothermal therapy, Acta Biomaterialia, 2020, 110, 242-253

19. Peng Liu, Xin Xie, Xinyi Shi, Ying Peng, Jinsong Ding and Wenhu Zhou*, Oxygen-Self-Supplying and HIF-1α-Inhibiting Core−Shell Nanosystem for Hypoxia-Resistant Photodynamic Therapy, ACS Appl. Mater. Interfaces 2019, 11, 48261−48270

20. Liang Li, Yingcai Meng, Ling Li, Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, A Tetrahedral DNA Nanoflare for Fluorometric Determination of Nucleic Acids and Imaging of MicroRNA Using Toehold Strands, Microchimica Acta, 2019, 186, 824

21. Yang Yihua, Wang Zhe, Peng Ying, Jinsong Ding* and Wenhu Zhou*, A Smart pH-Sensitive Delivery System for Enhanced Anticancer Efficacy via Paclitaxel Endosomal Escape, Frontiers in Pharmacology, 2019, DOI: 10.3389/fphar.2019.00010

22. Xiaoli Luo, Xin Xie, Yingcai Meng, Taoli Sun, Jinsong Ding* and Wenhu Zhou*, Ligands dissociation induced gold nanoparticles aggregation for colorimetric Al3+ detection, Analytica Chimica Acta, 2019, 1087, 9, 76-85

23. Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, An aptamer-tethered, DNAzyme-embedded molecular beacon for simultaneous detection and regulation of tumor-related genes in living cells, Analyst, 2019, 144, 5098-5107

24. Liu Peng, Guo Binbin, Wang Shengfeng, Jinsong Ding* and Wenhu Zhou*, A thermo-responsive and self-healing liposome-in-hydrogel system as an antitubercular drug carrier for localized bone tuberculosis therapy, International Journal of Pharmaceutics, 2019, 558, 101-109

25. Yang Chen, Cejun Yang, Juan Mao, Haigang Li, Ying, Jinsong Ding* and Wenhu Zhou*, Spermine Modified Polymeric Micelles with pH-Sensitive Drug Release for Targeted and Enhanced Antitumor Therapy, RSC Advances, 2019, 9, 11026-11037

26. Yingcai Meng, Peng Liu, Wenhu Zhou*, Jinsong Ding*, Juewen Liu, Bioorthogonal DNA Adsorption on Polydopamine Nanoparticles Mediated by Metal Coordination for Highly Robust Sensing in Serum and Living Cells, ACS Nano, 2018, 12, 9070-9080

27. Peng Liu, Shengfeng Wang, Xuanjun Liu, Jinsong Ding* and Wenhu Zhou*, Platinated graphene oxide: A nanoplatform for efficient gene-chemo combination cancer therapy, European journal of pharmaceutical sciences, 2018, 121, 319-329

28. Binbin Guo, Yuqiao Zhang, Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, The pharmacokinetics of morphine and codeine in human plasma and urine after oral administration of Qiangli Pipa Syrup, Journal of forensic science, 2018, 63, 1221-1228

29. Shengfeng Wang, Chuantong Zhao, Peng Liu, Zhe Wang, Jinsong Ding* and Wenhu Zhou*, Facile construction of dual-targeting delivery system by using lipid capped polymer nanoparticles for anti-glioma therapy. RSC Advances, 2018, 8, 444–453

30. Wenhu Zhou* and Juewen Liu*, "Multi-metal-dependent nucleic acid enzymes", Metallomics, 2018, 10, 30-48

31. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Splitting a DNAzyme enabling Na+-dependent FRET signal from the embedded aptamer", Organic & Biomolecular Chemistry, 2017, 15, 6959-6966

32. Wenhu Zhou, Runjhun Saran, Jinsong Ding and Juewen Liu*, "Two Completely Different Mechanisms for Highly Specific Na+ Recognition by DNAzymes", ChemBioChem, 2017, 18, 1828-1835

33. Wenhu Zhou, Runjhun Saran and Juewen Liu*, "Metal Sensing by DNA", Chemical Reviews, 2017, 117, 8272–8325

34. Wenhu Zhou, Runjhun Saran, Po-Jung Jimmy Huang, Jinsong Ding and Juewen Liu*, "An Exceptionally Selective DNA Cooperatively Binding Two Ca2+ Ions", ChemBioChem, 2017, 18, 518-522.

35. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Theranostic DNAzymes", Theranostics, 2017, 7, 1010-1025

36. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "2-Aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver", Biosensors & Bioelectronics, 2017, 87, 171-177

37. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A highly specific sodium aptamer probed by 2-aminopurine for robust Na+ sensing", Nucleic Acids Research, 2016, 44, 10377-10385

38. Wenhu Zhou, Tianmeng Yu, Mahsa Vazin, Jinsong Ding and Juewen Liu*, "Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis", Inorganic Chemistry, 2016, 55, 8193–8200

39. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence", ChemBioChem, 2016, 17, 1563–1570

40. Wenhu Zhou, Mahsa Vazin, Tianmeng Yu Jinsong Ding and Juewen Liu*, "In Vitro Selection of Chromium-Dependent DNAzymes for Sensing Cr(III) and Cr(VI)", Chemistry, a European Journal, 2016, 22, 9835-9840

41. Wenhu Zhou, Yupei Zhang, Jinsong Ding* and Juewen Liu*, "In Vitro Selection in Serum: RNA-Cleaving DNAzymes for Measuring Ca2+ and Mg2+", ACS Sensors, 2016, 1, 600-606

42. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "An Efficient Lanthanide-Dependent DNAzyme Cleaving 2’-5’ Linked RNA", ChemBioChem, 2016, 17, 890-894

43. Wenhu Zhou, Runjhun Saran, Qingyun Chen, Jinsong Ding and Juewen Liu*, "A New Na+-Dependent RNA-Cleaving DNAzyme with over 1000-fold Rate Acceleration by Ethanol", ChemBioChem, 2016, 17, 159-163

44. Wenhu Zhou, Yupei Zhang, Po-Jung Jimmy Huang, Jinsong Ding, and Juewen Liu*, "A DNAzyme requiring two different metal ions at two distinct sites", Nucleic Acids Research, 2016, 44, 354-363

45. Wenhu Zhou, Jinsong Ding* and Juewen Liu*, "A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold", Chemical Communications, 2015, 51, 12084-12087

46. Wenhu Zhou, Qingyun Chen, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "DNAzyme Hybridization, Cleavage, Degradation and Sensing in Undiluted Human Blood Serum", Analytical Chemistry, 2015, 87, 4001–4007

47. Wenhu Zhou, Feng Wang, Jinsong Ding* and Juewen Liu*, "Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles", ACS Applied Materials & Interfaces, 2014, 6, 14795-14800

48. Wenhu Zhou, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "Aptamer-based biosensors for biomedical diagnostics", Analyst, 2014, 139, 2627-2640

49. Wenhu Zhou, Yanbin Zhou, Jianping Wu, Zhenbao Liu, Huanzhe Zhao, Juewen Liu*, and Jinsong Ding*. "Aptamer-nanoparticle bioconjugates enhance Intracellular delivery of vinorelbine to breast cancer cells", Journal of Drug Targeting, 2014, 22(1): 57-66

50. Wenhu Zhou, Shiying He, Yijun Yang, Dan Jian, Xiang Chen*, and Jinsong Ding*," Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma”, Drug development and industrial pharmacy, 2015, 41 (7), 1109-1119

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