张 政

教授，博士生导师

药理学系

电话：0731-82355077

传真：0731-82355078

电子邮箱：zzhang@csu.edu.cn,zzhang510@gmail.com

学习工作经历

1998/09–2003/07，武汉大学，临床医学本科

2003/09–2008/07，中山大学，心血管药理学硕博连读

2008/09–2009/12，University of Connecticut Health Center，离子通道药理学博士后

2010/01–2013/01，The Queen’s Medical Center，离子通道药理学博士后

2013/02–至今，中南大学湘雅药学院药理学系

研究领域

心血管离子通道药理学；离子通道生物物理学；钙离子信号转导

部分发表论文

1.Huang EW, Liu CZ, Liang SJ,Zhang Z, Lv XF, Liu J, Zhou JG, Tang YB, Guan YY. Endophilin-A2-mediated increase in scavenger receptor expression contributes to macrophage-derived foam cell formation.Atherosclerosis.2016; 254:133-141.

2.Sponder G, Mastrototaro L, Kurth K, Merolle L,Zhang Z, Abdulhanan N, Smorodchenko A, Wolf K, Fleig A, Penner R, Iotti S, Aschenbach JR, Vormann J, Kolisek M. Human CNNM2 is not a Mg²⁺transporter per se.Pflugers Arch.2016; 468(7):1223-40.

3.Wang M, Tang YB, Ma MM, Chen JH, Hu CP, Zhao SP, Peng DQ, Zhou JG, Guan YY,Zhang Z. TRPC3 channel confers cerebrovascular remodelling during hypertension via transactivation of EGF receptor signalling.Cardiovasc Res.2016; 109(1):34-43.

4.Zhang Z, Faouzi M, Huang J, Geerts D, Yu H, Fleig A, Penner R. N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation.Oncotarget. 2014; 5(17):7625-34.

5.Zhang Z, Yu H, Huang J, Faouzi M, Schmitz C, Penner R, Fleig A. The TRPM6 kinase domain determines the MgATP-sensitivity of TRPM7/M6 heteromeric ion channels.J Biol Chem. 2014; 289(8):5217-27

6.Yu H,Zhang Z, Lis A, Penner R, Fleig A. TRPM7 is regulated by halides through its kinase domain.Cell Mol Life Sci.2013; 70(15):2757-71

7.Zhang Z, Wang M, Fan XH, Chen JH, Guan YY, Tang YB. Upregulation of TRPM7 channels by angiotensin II triggers phenotypic switching of vascular smooth muscle cells of ascending aorta.Circ Res. 2012;111(9):1137-46

8.Wang M, Yang H, Zheng LY,Zhang Z, Tang YB, Wang GL, Du YH, Lv XF, Liu J, Zhou JG, Guan YY. Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension by promoting basilar smooth muscle cell proliferation.Circulation. 2012;125:697-707

9.Shi XL, Wang GL,Zhang Z, Liu YJ, Chen JH, Zhou JG, Qiu QY, Guan YY. Alteration of volume-regulated chloride movement in rat cerebrovascular smooth muscle cells during hypertension.Hypertension.2007;49:1371-1377

10.Zierler S, Yao G,Zhang Z, Kuo WC, Porzgen P, Penner R, Horgen FD, Fleig A. Waixenicin a inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels.J Biol Chem. 2011;286:39328-39335

11.Du J, Xie J,Zhang Z, Tsujikawa H, Fusco D, Silverman D, Liang B, Yue L. TRPM7-mediated Ca²⁺signals confer fibrogenesis in human atrial fibrillation.Circ Res. 2010;106:992-1003

12.Chen HC, Xie J,Zhang Z, Su LT, Yue L, Runnels LW.Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase.PLoS One. 2010;5:e11161