一、个人简介
陈飞，副研究员，硕士生导师，湖南省优青。2008-2012本科毕业于华中科技大学同济药学院；2012-2015硕士毕业于国家纳米科学中心，师从梁兴杰教授；2015-2019博士毕业于德国马普高分子研究所，师从Katharina Landfester教授；2019-2020博士后工作于德国明斯特大学医学院生理病理研究所，合作导师Seraphine Wegner教授；2020年底入职中南大学湘雅药学院药物化学系。
主要从事疾病早期诊断与治疗研究，聚焦光动力、声动力抗菌及抗肿瘤创新药物开发，结合分子探针与生物材料探索诊疗新策略。目前主持湖南省自然科学基金优青项目，已主持完成国家自然科学基金青年项目、湖南省自然科学基金青年项目、湖南省教育厅优青项目等，并作为核心成员参与中德国际合作交流项目、国家自然科学基金面上项目及学科交叉研究。迄今发表SCI论文50余篇，其中以第一/通讯作者在Adv. Funct. Mater.、Small、Acta Pharm. Sin. B.、Adv. Sci.、Chem. Eng. J.、Matter、Biomaterials、J. Control. Release、Adv. Healthc. Mater.、Biomater. Res.、ACS Sens.、ACS Appl. Mater. Interfaces、ACS Synth. Biol.等国际期刊发表SCI论文20余篇（含1篇高被引论文、1篇自然指数期刊，6篇影响因子＞10的论文）；参编外文专著1部；申请国家发明专利8项（授权5项）；获得中华医学科技奖二等奖1项；担任Exploration、Smart Molecules、iRadiology期刊青年编委；担任Adv. Sci.、Acta Biomater.等期刊审稿人。
联系方式：fechen@csu.edu.cn
二、代表性研究论文
1.Zheng, Y.;1Chen, F.;1Frank, S.; Quispe Haro, J. J.; Wegner, S. V.* Three-Color ProteinPhotolithography with Green, Red, and Far-Red Light. Small2024,20, 2405687.（IF= 13.3）
2.Fan, D.; Xie, R.; Liu, X.; Li, H.; Luo, Z.; Li, Y.;Chen, F.,*Zeng, W. * A peptide-based pH-sensitive antibacterial hydrogel for healing drug-resistant biofilm-infected diabetic wounds. Journal of Materials Chemistry B 2024, 12 (22), 5525-5534.（IF= 6.1）
3.Luo, Z.; Cheng, X.; Feng, B.; Fan, D.; Liu, X.; Xie, R.; Luo, T.; Wegner, S. V.; Ma, D.;Chen, F.,*Zeng, W. * Engineering Versatile Bacteria-Derived Outer Membrane Vesicles: An Adaptable Platform for Advancing Cancer Immunotherapy. Advanced Science 2024, 11 (33), 2400049.（IF= 14.3）
4.Liu, X., Ren, Y., Fan, D., Huang, S., Ma, Y., Ding, J., Luo, Z.,Chen, F.,*Zeng, W. * Shining Light on Multidrug-Resistant Bacterial Infections: Rational Design of Multifunctional Organosilver-Based AIEgen Probes as Light-Activated Theranostics for Combating Biofilms and Liver Abscesses. Advanced Functional Materials 2023, 33,2304974.（IF= 18.5）
5.Fan, D.; Liu, X.; Ren, Y.; Luo, Z.; Li, Y.; Dong, J.; Wegner, S. V.;Chen, F.;* Zeng, W. * Harnessing antimicrobial peptide-coupled photosensitizer to combat drug-resistant biofilm infections through enhanced photodynamic therapy. Acta Pharmaceutica SinicaB 2024, 14(4), 1759-1771（IF= 14.8）
6.Zheng, F., Ma, Y., Ding, J., Huang, S., Zhang, S., Huang, X., Feng, B., Zeng, H.,Chen, F.,* Zeng, W. * Ratiometric and discriminative visualization of autophagic processes with a novel dual-responded lysosome-specific fluorescent probe. Biomaterials Research 2023, 27(1), 66-77.（IF=8.1）
7.Feng, B.; Ma, Y.; Zheng, F.; Huang, X.; Feng, X.; Zhang, K.; Liu, L.;Chen, F.;*Zeng, W., * Development of near-infrared lysosomal pH-activatable fluorescent probe for real-time visualization of autophagy progression. Chemical Engineering Journal 2023, 464, 142554.（IF= 13.4）
8.Huang, X.;1Chen, F.;1Ma, Y.; Zheng, F.; Fang, Y.; Feng, B.; Huang, S.; Zeng, H.; Zeng, W., De novo design of a novel AIE fluorescent probe tailored to autophagy visualization via pH manipulation. Biomaterials Research 2023, 27 (1), 20-37.（IF=8.1）
9.Liu, X.; Fan, D.; Ren, Y.; Huang, S.; Ding, J.; Liu, M.; Wegner, S. V.; Hou, J.; Rong, P.;Chen, F.;* Zeng, W., * Photo-Activable Organosilver Nanosystem Facilitates Synergistic Cancer Theranostics. ACS Appl. Mater. Interfaces 2023, 15 (1), 711-722.（IF=8.5）
10.Fan, D.; Liu, X.; Ren, Y.; Bai, S.; Li, Y.; Luo, Z.; Dong, J.;Chen, F.;*Zeng, W., *Functional insights to the development of bioactive material for combating bacterial infections. Front. Bioeng. Biotechnol. 2023, 11, 1186637.（IF=4.3）
11.Chen, F.; Dong, J.; Sun, W.; Di Iorio, D.; Wegner, S. V.; Zeng, W. Editorial: Construction of smart materials for biomedical application. Frontiers in Bioengineering and Biotechnology 2023, 11, 1278243.（IF=4.3）
12.Chen, F., Zeng, W., and Wegner, S. V. (2022).Ultrasound-activated bacteria with thermostat controls as living therapeutics. Matter 5, 2416–2419. (IF= 18.4)
13.Liu, X.; Fan, D.; Feng, X.; Zheng, Y.; Wegner, S. V.; Liu, M.;Chen, F.;* Zeng, W. * (2022).Breaching Bacterial Biofilm Barriers: Efficient Combinatorial Theranostics for Multidrug-Resistant Bacterial Biofilms with a Novel Penetration-Enhanced AIEgen Probe. ACS Appl. Mater. Interfaces 14 (37), 41671-41683.（IF=8.5）
14.Zheng, F.; Huang, X.; Ding, J. P.;Bi, A.; Wang, S.;Chen, F.;*Zeng, W.,*NIR-I Dye-Based Probe: A New Window for Bimodal Tumor Theranostics.Frontiers in Chemsitry2022, 10 (1), 1-23.（IF=3.8）
15.Song, R.; Ma, Y.; Bi, A.; Feng, B.; Huang, L.; Huang, S.; Huang, X.; Yin, D.;Chen, F.;* Zeng, W.,*Highly selective and sensitive detection of arsenite ions(iii) using a novel tetraphenylimidazole-based probe.Analytical Methods2021, 13 (42), 5011-5016.（IF=2.7）
16.Chen, F.; Wegner, S. V., Photoswitchable bacteria-bacteria adhesions enable the control of multicellular bacterial communities by using blue light.ACS Synthetic Biology2020, 9 (5), 1169–1180.（IF=3.8）
17.Chen, F.; Rachel L. Warnock, Jan Roelof Van der Meer,Wegner, S. V., Bioluminescence-Triggered Photoswitchable Bacterial Adhesions enable Higher Sensitivity and Dual-readout Bacterial Biosensors for Mercury.ACS Sensors2020, 5 (7), 2205–2210.(IF=8.9)
18.Chen, F.;Ricken, J.;Xu, D.; Wegner, S. V., Bacterial Photolithography: Patterning Escherichia coli Biofilms with High Spatial Control Using Photocleavable Adhesion Molecules.Advanced Biosystems2019, 3 (3), 1800269.（IF=3.2）
19.Chen, F.; Wegner, S. V., Implementation of Blue Light Switchable Bacterial Adhesion for Design of Biofilm.Bio-protocol,2018, 8 (12), e2893.
20.Chen, F.; Wegner, S. V., Blue Light Switchable Bacterial Adhesion as a Key Step toward the Design of Biofilms.ACS Synthetic Biology2017, 6 (12), 2170-2174.（IF=3.8）
21.Zhao, Y.;1Chen, F.;1Pan, Y.; Li, Z.; Xue, X.; Okeke, C. I.; Wang, Y.; Li, C.; Peng, L.; Wang, P. C.; Ma, X.; Liang, X. J., Nanodrug Formed by Coassembly of Dual Anticancer Drugs to Inhibit Cancer Cell Drug Resistance.ACS applied materials & interfaces2015, 7 (34), 19295-305.（IF=8.5）
22.Chen, F.; Zhao, Y.; Pan, Y.; Xue, X.; Zhang, X.; Kumar, A.; Liang, X. J., Synergistically Enhanced Therapeutic Effect of a Carrier-Free HCPT/DOX Nanodrug on Breast Cancer Cells through Improved Cellular Drug Accumulation.Molecular pharmaceutics2015, 12 (7), 2237-44.（IF= 4.5）
23.Kumar, A.;1Chen, F.;1Mozhi, A.; Zhang, X.; Zhao, Y.; Xue, X.; Hao, Y.; Zhang, X.; Wang, P. C.; Liang, X. J., Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation.Nanoscale2013, 5 (18), 8307-8325.（IF=8.0）
三、专利
1.梁兴杰;陈飞;赵元元;一种多药自聚复合纳米粒子、其制备方法和应用, 2016-09-07,中国, 201310533322.8（已授权）
2.梁兴杰;赵元元;陈飞;马晓溦;李盛亮;薛向东;柳娟;金叔斌;李鸿基;张吉梅;王义峰;甘雅玲;姜永刚;羟基喜树碱纳米脂束制剂及其制备方法, 2016-1-20,中国, 201410016965.X（已授权）
3.梁兴杰;赵元元;柳娟;李盛亮;薛向东;陈飞;金叔宾;张吉梅;李鸿基;甘雅玲;姜永刚;一种伊立替康纳米脂束制剂及其制备方法, 2016-6-29,中国, 201410014128.3（已授权）
4.梁兴杰;李婵;张春秋;陈飞;金叔宾;王浩;吴雁;杨蓉;一种盐酸伊立替康纳米脂束制剂及其制备方法, 2015-11-4,中国, 201410344489.4（已授权）
5.陈飞;谢如燕;曾文彬;范多阳;李昊翰;一种光动力靶向抗菌微针贴片及其制备方法和应用, 2025-3-5,中国, 202510256204.X
6.曾文彬;刘小辉;陈飞;董界;范多阳;罗子恒;一种光激活肿瘤化学光动力学治疗的诊疗一体化纳米材料及其制备方法和应用, 2022-12-22,中国, 202211654902.8
7.曾文彬;刘美慧;刘小辉;陈飞;李石;谢成昆;刘祖源;芳基连二咪唑类化合物、制备方法及其医药用途, 2024-7-16,中国, 202210877081 .8（已授权）
8.曾文彬;范多阳;陈飞;刘小辉;董界;罗子恒;李艳冰;一种新型多肽偶联药物化合物及其制备方法与应用, 2023-12-12,中国, 202311701040.4
