张艳文，女，博士，中南大学湘雅药学院特聘副教授，硕士生导师，河南鹤壁人。2015年和2021年分别获得湖南大学学士与博士学位，2021-2024年在湖南大学化学化工学院开展博士后研究。邮箱：224176@csu.edu.cn

研究领域：

1.微纳载体/微反应器的构建和功能组装，人工细胞模型的化学构建及其生物医学应用。

2.基于非共价相互作用驱动的自组装；液液相分离。

教育经历：

2015.09-2021.07湖南大学化学化工学院 博士 分析化学专业 直博 导师:刘剑波 教授

2011.09-2015.06湖南大学化学化工学院 学士 化学专业

工作履历：

2021.10-2024.07湖南大学化学化工学院 博士后化学工程与技术流动站 导师:刘剑波 教授

2024.09-至今 中南大学湘雅药学院 特聘副教授

主持科研项目：

国家自然科学基金,青年科学基金项目, 22307035,30万元, 2024.01-2026.12,在研，主持;

中国博士后科学基金会，中国博士后科学基金第72批面上资助, 2022M721088，8万元,2023.01-2025.12,在研，主持；

湖南省自然科学基金,青年基金项目, 2023JJ40135,5万元,2023.01-2025.12,在研，主持

荣誉与奖励：

湖南大学优秀博士论文,2023年;

中国化学会第七届“菁青论坛”优秀研究生报告奖,2023年;

第三届全国化学专业大学生科技活动交流会墙报类二等奖,2013年

代表论文：

[1]Yanwen Zhang, Yufeng Chen, Xiaohai Yang, Xiaoxiao He, Mei Li, Songyang Liu, Kemin Wang, Jianbo Liu,* Stephen Mann.* Giant coacervate vesicles as an integrated approach to cytomimetic modeling.Journal of the American Chemical Society, 2021, 143(7): 2866-2874.IF 15.0, Q1

[2]Yanwen Zhang#, Zefeng Wang# (co-author), Mei Li, Can Xu, Ning Gao, Zhuping Yin, Kemin Wang, Stephen Mann,* Jianbo Liu.* Osmotic-induced reconfiguration and activation in membranized coacervate-based protocells.Journal of the American Chemical Society, 2023, 145(18): 10396-10403.IF 15.0, Q1

[3]Songyang Liu#,Yanwen Zhang#(co-author), Xiaoxiao He, Mei Li, Jin Huang, Xiaohai Yang, Kemin Wang, Stephen Mann,* Jianbo Liu.* Signal processing and generation of bioactive nitric oxide in a model prototissue.Nature Communications, 2022, 13, 5254.IF16.6, Q1

[4]Yanwen Zhang, Songyang Liu, Yu Yao, Yufeng Chen, Shaohong Zhou, Xiaohai Yang, Kemin Wang,* Jianbo Liu.* Invasion and defense interactions between enzyme‐active liquid coacervate protocells and living cells.Small, 2020, 29(16): 2002073. IF 13.3, Q1

[5]Yanwen Zhang, Shixin Wang, Yuling Yan, Xiaoxiao He, Zefeng Wang, Shaohong Zhou, Xiaohai Yang, Kemin Wang, Jianbo Liu.* Phase-separated bienzyme compartmentalization as artificial intracellular membraneless organelles for cell repair.Science China-Chemistry, 2023, 66, 845-852. IF 9.6, Q1

[6]Yanwen Zhang, Yu Yao, Songyang Liu, Yufeng Chen, Shaohong Zhou, Xiaohai Yang,* Kemin Wang, Jianbo Liu.* Coacervate microdroplet protocells-mediated gene transfection for nitric oxide production and induction of cell apoptosis.Journal of Materials Chemistry B, 2021, 9, 9784-9793. IF 7.0, Q1

[7]Miaomiao Zhuang#,Yanwen Zhang# (co-author), Shaohong Zhou, Yun Zhang, Kemin Wang, Jinfang Nie, Jianbo Liu.* Uricase-containing coacervate microdroplets as enzyme active membrane-free protocells for detoxification of uric acid in serum.Chemical Communications, 2019, 55: 13880-13883. IF 4.9, Q2

[8]Yu Yao#,Yanwen Zhang# (co-author), Li Li, Yan Huang, Xiaohai Yang, Zhihong Peng,* Kemin Wang, Jianbo Liu.* Photothermally activated coacervate protocells as signal transducers endow mammalian cells with light sensitivity.Advanced Biology, 2021, 5(8): 2100695. IF 3.7, Q3

[9]Songyang Liu,Yanwen Zhang, Mei Li, Li Xiong, Zijian Zhang, Xiaohai Yang, Xiaoxiao He, Kemin Wang, Jianbo Liu,* Stephen Mann.* Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells.Nature Chemistry, 2020, 12: 1165-1173. IF 21.8, Q1

[10]Qiaoshu Chen,Yanwen Zhang, Hui Chen, Jianbo Liu,* Junwen Liu.* Enhancing the sensitivity of DNA and aptamer probes in the Dextran/PEG aqueous two-phase system.Analytical Chemistry, 2021, 93: 8577-8584. IF 7.418, Q1

[11]Xi Guo,Yanwen Zhang, Jianbo Liu,* Xiaohai Yang, Jin Huang, Li Li, Lan Wan, Kemin Wang.* Red blood cell membrane-mediated fusion of hydrophobic quantum dots with living cell membranes for cell imaging.Journal of Materials Chemistry B, 2016, 4: 4191-4197. IF 7.0, Q1

[12]Yufeng Chen,Yanwen Zhang, Mei Li, Songyang Liu, Xiaohai Yang, Kemin Wang, Stephen Mann,* Jianbo Liu.* Self-immobilization of coacervate droplets by enzyme-mediated hydrogelation.Chemical Communications, 2021, 57: 5438-5441. IF 4.9, Q2

[13]Yufeng Chen, Min Yuan,Yanwen Zhang, Songyang Liu, Xiaohai Yang, Kemin Wang,* Jianbo Liu.* Construction of coacervate-in-coacervate multi-compartment protocells for spatial organization of enzymatic reactions.Chemical Science, 2020, 11: 8617-8625. IF 8.4, Q1

[14]Yufeng Chen, Min Yuan,Yanwen Zhang, Shaohong Zhou, Kemin Wang, Zhenjun Wu*, Jianbo Liu.* Enzyme-active liquid coacervate microdroplets as artificial membraneless organelles for intracellular ROS scavenging.Biomaterial Science, 2022,10, 4588-4595. IF 6.6, Q1

[15]Shaohong Zhou, Xueer Cai,Yanwen Zhang, Qiaoshu Chen, Xiaohai Yang, Kemin Wang, Lixin Jian,* Jianbo Liu.* DNA nanotubes in coacervate microdroplets as biomimetic cytoskeletons modulate the liquid fluidic properties of protocells.Journal of Materials Chemistry B, 2022, 10, 8322-8329. IF 7.0, Q1

[16]Zefeng Wang, Min Zhang, Yan Zhou,Yanwen Zhang, Kemin Wang, Jianbo Liu.* Coacervate Microdroplets as Synthetic Protocells for Cell Mimicking and Signaling Communications.Small Methods, 2023, https://doi.org/10.1002/smtd.202300042, IF 12.4, Q1

[17]Lang Chen, Jie He, Qing Yuan,Yanwen Zhang, Fu Wang, Chak-Tong Au, Shuangfeng Yin.* CuS–Bi2S3 hierarchical architectures: controlled synthesis and enhanced visible-light photocatalytic performance for dye degradation.RSC Advances, 2015, 5: 33747-33754. IF 3.9, Q2