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师资队伍

周文虎教授
发布时间:2024/01/05   阅读量:

 

周文虎

中南大学,湘雅药学院,三级教授,博士生导师

邮箱:zhouwenhuyaoji@163.com;

 zhouwenhu@csu.edu.cn

 

教育经历:

本硕博均毕业于中南大学湘雅药学院,博士期间获国家留学基金委资助赴加拿大滑铁卢大学进行联合培养,获湖南省优秀博士学位论文。

 

工作经历:历任中南大学湘雅药学院药剂学系主任,现任湘雅药学院副院长。

 

研究领域:新型药物制剂、皮肤医用医疗器械与化妆品研究

 

招生方向:药学(药剂学);生物医药

 

社会兼职

Exploration杂志科学编辑,Acta Pharm. Sin. B, Asian J. Pharm. Sci., Chin. Chem. Lett., Chin. J. Cancer Res.杂志青年编委,肿瘤药学杂志编委。任中国药学会药剂专委会青年委员,中国颗粒学会青年理事,湖南省肿瘤药物研究与转化专委会副主任委员,湖南省药学会药剂专委会委员,

 

人才项目及获奖:

湖南省科技人才托举工程,年轻优秀科技人才,湖南省科协,2020

湖南省优秀青年基金,肿瘤药剂学,湖南省科技厅,2021

湖湘青年英才,湖南省科技厅,2021

医学学科青年骨干人才,湖南省卫生健康委,2023

湖南省自然科学二等奖(排名第一)

指导大学生创新创业大赛国家级奖项6项,省级奖项5项(互联网+,挑战杯等)

 

科研成果:

Ø  主持科研项目:

纵向国家级项目

国家自然科学基金,可突破免疫屏障的“隐形”沙门氏菌联合放疗免疫增敏用于宫颈癌的治疗研究

国家自然科学基金,基于功能核酸串联的诊疗一体化探针的构建与应用研究

 

横向项目

校企合作科研项目20余项

 

Ø  授权发明专利:

以第一发明人授权国家发明专利13项,已完成转让专利10项,部分专利列举如下:

1.      纳米配位聚合物及其制备方法和应用,ZL 201910805848.4排名第一,授权公告日:20200623

2.      一种抑制活化巨噬细胞增殖的聚合物/银活性键合物及其制备和应用,ZL 201910374069.3排名第一,授权公告日:20200616

3.      一种酸性环境中可降解的表面涂层及其制备方法与应用,ZL 202010675017.2排名第一,授权公告日:20210413

4.      一种电荷可控的聚合物材料及其制备方法与应用,ZL 202010676053.0排名第一,授权公告日:20210723

5.      一种DNA/纳米复合物及其制备方法与应用,ZL 202110041560.1排名第一,授权公告日:20220628

6.      包载甲氨蝶呤的铁-鞣酸配合物及其制备方法和应用,ZL202010903340.0排名第一,授权公告日:20220812

7.      一种具有粘液渗透的核酸纳米载体及其制备方法与应用,ZL202111304068.5排名第一,授权公告日:20221125

8.      雄黄纳米粒的制备方法和应用,ZL202010887138.3排名第一,授权公告日:20221125

9.      一种多酚自聚纳米粒及其制备方法与应用,ZL 2021 1 1433444.0排名第一,授权公告日:20240503

10.  一种基于 DNAzyme 调控基因编辑的方法,ZL 202111160432.5排名第一,授权公告日:20220304

11.  核酸检测探针及其制备方法,排名第二ZL 202110532356,授权公告日:2021-08-24

 

 

代表性论文

以(共同)通讯作者身份在Adv. Funct. Mater., ACS Nano2篇), Acta Pharm. Sin. B4篇), J. Control. Release3篇), Adv. Sci.等国际权威期刊发表SCI论文84篇,IF>10分论文30篇;高被引论文10篇,热点论文4篇,总被引6132次,单篇最高被引次801次,H指数41入选全球前2%顶尖科学家20232024年榜单,部分论文列举如下:

1.         Yujie Fan, Yangqin Ou, Ting Xiao, Ziye Wei, LiLing Zhu, Chenghao Zhu, Yiran Ma, Shuangquan Qu*, Wenhu Zhou*, Coordination-Driven Nanomedicine Mitigates One-Lung Ventilation-Induced Lung Injury via Radicals Scavenging and Cell Pyroptosis Inhibition, Small 2024, 2401056

2.         Ying Zhou, Yunxiao Ma, Jianwei Sheng, Yiran Ma, Jinsong Ding*, Wenhu Zhou*, Breaking Down Barriers in Drug Delivery by Stromal Remodeling Approaches in Pancreatic Cancer, Mol. Pharmaceutics 2024, 21, 8, 3764–3776

3.         Aiping Huang, Qingnian Li, Xinyi Shi, Junyi Gao, Yiran Ma, Jinsong Ding, Surong Hua*, Wenhu Zhou*, An iron-containing nanomedicine for inducing deep tumor penetration and synergistic ferroptosis in enhanced pancreatic cancer therapy, Materials Today Bio, 2024, 27, 101132

4.         Shan Lu, Ze Mi, Peng Liu, Jinsong Ding, Yiran Ma, Jieru Yang*, Pengfei Rong*, Wenhu Zhou*, Repolarizing neutrophils via MnO2 nanoparticle-activated STING pathway enhances Salmonella-mediated tumor immunotherapy, J Nanobiotechnol, 2024 22, 443

5.         Youwei Xu, Zhonghui Zheng, Qing Lin, Jiaxin Huang, Jinsong Ding, Wenhu Zhou*, Structure Determination and 3D ED/MicroED-Guided Synthesis of a New (S)-Ibuprofen–l-phenylalanine Co-Crystal, Cryst. Growth Des. 2024, 24, 12, 4924–4929

6.         Ming Zhou, Xiaoqin Yin, Bei Chen, Shuo Hu*, Wenhu Zhou*, A PET probe targeting polyamine transport system for precise tumor diagnosis and therapy, Asian Journal of Pharmaceutical Sciences, 2024, 19, 100924

7.         Yingcai Meng, Jiaxin Huang, Jinsong Ding, Haiyan Zhou*, Yong Li*, Wenhu Zhou*, Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy, Materials Today Bio, 2024, 26, 101018

8.         Ying Wang, Yiyan Xu, Jiayu Song, Xueting Liu, Sijia Liu, Nan Yang, Le Wang, Yujie Liu, Yiwei Zhao, Wenhu Zhou*, Yunyan Zhang*, Tumor Cell-Targeting and Tumor Microenvironment–Responsive Nanoplatforms for the Multimodal Imaging-Guided Photodynamic/Photothermal/Chemodynamic Treatment of Cervical Cancer, Int J Nanomedicine. 2024;19:5837-5858

9.         Hui Wang, Cui Tang, Yuxia Xiang, Chan Zou, Jianming Hu, Guoping Yang*, Wenhu Zhou*, Tea polyphenol-derived nanomedicine for targeted photothermal thrombolysis and inflammation suppression, J Nanobiotechnol, 2024, 22, 146

10.     Jing Wang, Nuli Xie, Shan Lu, Bo Xiao, Yangqin Ou, Qingnian Li, Dexian Liu, Wenhu Zhou*, CpG and Rutin Co-Loaded DNA Tetrahedra for Targeted Therapy of Intracerebral Hemorrhage: Synergistic Hematoma Clearance and Neuroinflammation Inhibition, Advanced Functional Materials, 2024, 2403469.

11.     Jiaojiao Zhu, Lanyuan Peng, Shah Jehan, Haiyang Wang, Xiang Chen, Shuang Zhao, and Wenhu Zhou*, Activable Photodynamic DNA Probe with an "AND" Logic Gate for Precision Skin Cancer Therapy, Research, 2024, DOI: 10.34133/research.0295

12.     Xueming Xua, Yuanfeng Han, Jiali Deng, Shengfeng Wang, Shijie Zhuo, Kai Zhao,* Wenhu Zhou*, Repurposing disulfiram with CuET nanocrystals: Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases, Acta Pharmaceutica Sinica B, 2024

13.     Xurui Gu, Kun Liu, Yixuan Deng, Bixiao Xiang, Lingyun Zhou, Wenjun Yin, Jiaxin Huang, Yingcai Meng, Dianke Li, Ruiman Que, Zhiyao Tang, Guangliang Zhou, Yifeng Wu, Yujie Huang, Wenhu Zhou*, Xiaocong Zuo*, A Renal-Targeted Gene Delivery System Derived from Spermidine for Arginase-2 Silencing and Synergistic Attenuation of Drug-Induced Acute Kidney Injury, Chemical Engineering Journal, 2024, 486, 150125

14.     Yuanzheng Chen, Jiaojiao Zhu, Jinsong Ding, Wenhu Zhou, Recent progress of vaccines administration via microneedles for cancer immunotherapy, Chinese Chemical Letters, 2024, 35, 108706

15.     Lina Guo, Jinsong Ding, Wenhu Zhou*, Harnessing bacteria for tumor therapy: Current advances and challenges, Chinese Chemical Letters, 2024, 35, 108557

16.     Ying Peng, Peng Liu, Jinsong Ding, Wenhu Zhou*, Biomineralized nanomedicine for enhanced cancer therapy through in situ toxification and amplified Ca2+ overload, Chemical Engineering Journal, 2023, 475, 146277

17.     Lina Guo, Jinsong Ding, Wenhu Zhou*, Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy, Acta Pharmaceutica Sinica B, 2023, 13(12): 5074–5090.

18.     Jiaojiao Zhu+, Tiao Wen+, Shuangquan Qu, Qingnian Li, Biwu Liu, and Wenhu Zhou*, G-quadruplex/Hemin DNAzyme-Functionalized Silver Nanoclusters with Synergistic Anti-Bacterial and Wound Healing Capabilities for Infected Wound Management, Small, 2023, 2307220

19.     Lina Guo, Hao Chen, Jinsong Ding, Pengfei Rong, Ming Sun, Wenhu Zhou*, Surface engineering Salmonella with pH-responsive polyserotonin and self-activated DNAzyme for better microbial therapy of tumor, Exploration 2023, 00, 20230017

20.     Cui Tang, Hui Wang, Lina Guo, Chan Zou, Jianming Hu, Hanyong Zhang, Wenhu Zhou*, and Guoping Yang*, CpG Conjugated Silver Nanoparticle as Multifunctional Nanomedicine to Promote Macrophage Efferocytosis and Re-polarization for Atherosclerosis Therapy, ACS Appl. Mater. Interfaces 2023, 15, 45, 52162–52179

21.     Xiangcheng Zhao, Nuli Xie, Hailong Zhang, Wenhu Zhou*, and Jinsong Ding*, Bacterial Drug Delivery Systems for Cancer Therapy: “Why” and “How”, Pharmaceutics, 2023, 15(9), 2214

22.     Hao Chen, Lina Guo, Jinsong Ding, Wenhu Zhou*, Yan Qi, A General and Efficient Strategy for Gene Delivery Based on Tea Polyphenols Intercalation and Self-Polymerization, Advanced Science, 2023, 2302620.

23.     Zhang, Hui; Wang, Laifa; Zhu, Bi; Yang, Yongping; Cai, Chuanhai; Wang, Xueqin; Deng, Ling; He, Binsheng; Cui, Yanhui*, Wenhu Zhou*, A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats, European Journal of Pharmacology, 2023, 951, 15, 175801

24.     Liping Dong, Jinsong Ding, Lemei Zhu, Yujun Liu, Xiang Gao*, Wenhu Zhou*, Copper carbonate nanoparticles as an effective biomineralized carrier to load macromolecular drugs for multimodal therapy, Chinese Chemical Letters, 2023, 34, 108192

25.     Yingcai Meng, Jiaxin Huang, Jinsong Ding, Bohua Yan, Yong Li*, Xiang Gao*, Wenhu Zhou*, Poly-thymine DNA templated MnO2 biomineralization as a high-affinity anchoring enabling tumor targeting delivery, Journal of Colloid and Interface Science, 2023, 637, 441-452

26.     Shu Huang, Jun Yuan, Yong Xie, Kai Qing, Zeya Shi, Guanyu Chen, Jie Gao, Haoxiang Tan, Wenhu Zhou*, Targeting nano-regulator based on metal–organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer, Cancer Nanotechnology, 2023, 14, 43

27.     Aiping Huang, Wenhu Zhou*, Mn-based cGAS-STING activation for tumor therapy. Chin J Cancer Res 2023; 35(1):19-43.

28.     Hui Zhang†, Laifa Wang†, Yongping Yang, Chuanhai Cai, Xueqin Wang, Ling Deng, Binsheng He, Wenhu Zhou* and Yanhui Cui*, DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress, Frontiers in Pharmacology, 2023, DOI: 10.3389/fphar.2022.987293

29.     Lingjiao Li†, Shengmei Wang† and Wenhu Zhou*, Balance Cell Apoptosis and Pyroptosis of Caspase-3-Activating Chemotherapy for Better Antitumor Therapy, Cancers, 2023, 15, 26

30.     Jia Guo+, Peng Liu+, Benliang Wei+, Ying Peng, Jinsong Ding, Hailun Zhang, Guanxiong Zhang, Juan Su*, Hong Liu*, Wenhu Zhou*, Xiang Chen*, Reversing the Negative Effect of Adenosine A1 Receptor-Targeted Immunometabolism Modulation on Melanoma by a Co-delivery Nanomedicine for Self-activation of anti-PD-L1 DNAzyme, Nano Today, 2023, 48, 101722

31.     Xiaoxiong Xiao, Min Chen, Yuchen Zhang, Liang Li, Ying Peng, Junyu Li* and Wenhu Zhou*, Hemin-incorporating DNA nanozyme enabling catalytic oxygenation and GSH depletion for enhanced photodynamic therapy and synergistic tumor ferroptosis, Journal of Nanobiotechnology, 2022, 20:410

32.     Jiaojiao Zhu+, Ruimin Chang+, Benliang Wei, Yao Fu, Xiang Chen*, Hong Liu*, and Wenhu Zhou*, Photothermal Nano-Vaccine Promoting Antigen Presentation and Dendritic Cells Infiltration for Enhanced Immunotherapy of Melanoma via Transdermal Microneedles Delivery, Research, 2022, DOI10.34133/2022/9816272

33.     Jiahao Liu#, Lina Guo#, Ze Mi, Liu Zhenguo, Pengfei Rong* and Wenhu Zhou*, Vascular Bursts-Mediated Tumor Accumulation and Deep Penetration of Spherical Nucleic Acids for Synergistic Radio-Immunotherapy, Journal of Controlled Release, 2022, 348, 1050-1065

34.     Ze Mi#, Qing Yao#, Yan Qi, Jinhai Zheng, Jiahao Liu, Zhenguo Liu, Hongpei Tan, Xiaoqian Ma, Wenhu Zhou*, Pengfei Rong*, Salmonella-Mediated Blood-Brain Barrier Penetration, Tumor Homing and Tumor Microenvironment Regulation for Enhanced Chemo/Bacterial Glioma Therapy, Acta Pharmaceutica Sinica B, 2023, 819-833

35.     Shengmei Wang1,4#, Xuanjun Liu1,2#, Minghua Yang3, Linqi Ouyang4, Jinsong Ding2, Shengfeng Wang*1,2,3, and Wenhu Zhou*, Non-cytotoxic Nanoparticles Re-educating Macrophages Achieving both Innate and Adaptive Immune Responses for Tumor Therapy, Asian Journal of Pharmaceutical Sciences, 2022, 17 (4) 557-570

36.     Yingcai Meng, Jiaojiao Zhu, Jinsong Ding, Wenhu Zhou*, Polyserotonin as a Versatile Coating with pH-responsive Degradation for Anti-tumor Therapy, Chem. Commun., 2022,58, 6713-6716

37.     Jiali Deng+, Rui Wang+, Jinsong Ding* and Wenhu Zhou*, Macrophages-Regulating Nanomedicines for Sepsis Therapy, Chinese Chemical Letters, 2023,34, 107588

38.     Lina Guo+, Shenghui Zhong+, Peng Liu, Man Guo, Jinsong Ding and Wenhu Zhou*, Radicals Scavenging MOFs Enabling Targeting Delivery of siRNA for Rheumatoid Arthritis Therapy, Small, 2022, 27, 2202604

39.     Hanane Aliouat#, Ying Peng#, Zoya Waseem, Shengfeng Wang, and Wenhu Zhou*, Pure DNA scaffolded Drug Delivery Systems for Cancer Therapy, Biomaterials, 2022, 285, 121532

40.     Mengzhen Yu#, Yanwen Zhang#, Meirong Fang, Shah Jehan* and Wenhu Zhou*, Current Advances of Nanomedicines Delivering Arsenic Trioxide for Enhanced Tumor Therapy, Pharmaceutics, 2022, 14(4), 743

41.     Qin Ouyang#, Kai Liu#, Qubo Zhu#, Huiyin Deng, Yuan Le, Wen Ouyang, Xiaoxin Yan, Wenhu Zhou*, Jianbin Tong*, Brain-Penetration and Neuron-Targeting DNA Nanoflowers Co-Delivering miR-124 and Rutin for Synergistic Therapy of Alzheimer's Disease, Small, 2022, 2107534

42.     Weidong Sun#, Yiyan Xu#, Ye Yao, Jie Yue, Zhen Wu, Haocheng Li, Guanghui Shen, Yan Liao, Haiyang Wang*, and Wenhu Zhou*, Self-oxygenation Mesoporous MnO2 Nanoparticles with Ultra-High Drug Loading Capacity for targeted Arteriosclerosis Therapy, Journal of Nanobiotechnology, 2022, 20, 88

43.     Yuan Chen#, Ruiheng Luo#, Jing Li#, Shengfeng Wang, Jinsong Ding, Kai Zhao*, Ben Lu* and Wenhu Zhou*, Intrinsic Radical Species Scavenging Activities of Tea Polyphenols Nanoparticles Blocks Pyroptosis in Endotoxin-Induced Sepsis, ACS Nano, 2022, 16, 2429-2441

44.     Peng Liu+, Ying Peng, Jinsong Ding and Wenhu Zhou*, Fenton Metal Nanomedicines for Imaging-guided Combinatorial Chemodynamic Therapy against Cancer, Asian Journal of Pharmaceutical Sciences, 2022, 17, 177-192

45.     Yuejia Song, Yaqian Huang, Fang Zhou, Jinsong Ding*, Wenhu Zhou*, Macrophage-targeted nanomedicine for chronic diseases immunotherapy, Chinese Chemical Letters, 2022, 33, 597-612

46.     Jiaojiao Zhu, Man Guo, Yanhui Cui, Yingcai Meng, Jinsong Ding, Wenbin Zeng, and Wenhu Zhou*, Surface Coating of Pulmonary siRNA Delivery Vectors Enabling Mucus Penetration, Cell Targeting, and Intracellular Radical Scavenging for Enhanced Acute Lung Injury Therapy, ACS Appl. Mater. Interfaces 2022, 14, 4, 5090–5100

47.     Shah Jehan, Jiaxin Huang, Umar Farooq, Irum Basheer and Wenhu Zhou*, Combinatorial effect of thymoquinone with chemo agents for tumor therapy, Phytomedicine, 2022, 98, 153936

48.     Pingping Bing, Wenhu Zhou* and Songwen Tan*, Study on the Mechanism of Astragalus Polysaccharide in Treating Pulmonary Fibrosis Based on “Drug-Target-Pathway” Network, Front. Pharmacol.,2022, 13:865065.

49.     Peng Liu+, Xinyi Shi+, Ying Peng, Jianming, Hu, Jinsong Ding and Wenhu Zhou*, Anti-PD-L1 DNAzyme Loaded Photothermal Mn2+/Fe3+ Hybrid Metal-Phenolic Networks for Cyclically Amplified Tumor Ferroptosis-Immunotherapy, Advanced Healthcare Materials, 2022, 11, 2102315

50.     Shengmei Wang, Xuanjun Liu, Shengfeng Wang, Linqi Ouyang, Hui Li, Jinsong Ding, Guiming Deng*, and Wenhu Zhou*, Imatinib co-loaded targeted realgar nanocrystal for synergistic therapy of chronic myeloid leukemia, Journal of Controlled Release, 2021, 338, 190-200

51.     Yang Zeng, Haiyan Zhou, Jinsong Ding, and Wenhu Zhou*, Cell membrane inspired nano-shell enabling long-acting Glucose Oxidase for Melanoma starvation therapy via microneedles-based percutaneous delivery, Theranostics, 2021; 11:8270-8282

52.     Peng Liu, Yanbin Zhou, Xinyi Shi, Yu Yuan, Ying Peng, Jinsong Ding, Yong Li*, and Wenhu Zhou*, A Cyclic Nano-reactor Achieving Enhanced Photodynamic Tumor Therapy by Reversing Multiple Resistances, J. Nanobiotechnol., 2021, 19, 149

53.     Peng Liu, Ying Peng, Yanbin Zhou, Xinyi Shi, Qingnian Li, Jinsong Ding, Yang Gao,* and Wenhu Zhou*, Rapamycin as a “One-Stone-Three-Birds” Agent for Cooperatively Enhanced Phototherapies Against Metastatic Breast Cancer, ACS Appl. Mater. Interfaces, 2021, 13, 22, 25674–25684

54.     Peng Liu, Xinyi Shi, Shenghui Zhong, Ying Peng, Yan Qi, Jinsong Ding, Wenhu Zhou*, Metal-phenolic networks for cancer theranostics, Biomater. Sci., 2021,9, 2825-2849

55.     Shenghui Zhong, Peng Liu, Jinsong Ding* and Wenhu Zhou*, Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy, Crystals, 2021, 11(4), 321-334

56.     Man Guo, Yingcai Meng, Xiaoqun Qin*, and Wenhu Zhou*, Dopamine-Grafted Hyaluronic Acid Coated Hyperbranched Poly(β-Amino Esters)/DNA Nano-Complexes for Enhanced Gene Delivery and Biosafety, Crystals, 2021, 11(4), 347-360

57.     Yang Xi, Xin Xie, Ying Peng, Peng Liu, Jinsong Ding* and Wenhu Zhou*, DNAzyme-adsorbed polydopamine@MnO2 core–shell nanocomposites for enhanced photothermal therapy via the self-activated suppression of heat shock protein 70, Nanoscale, 2021, 13, 5125-5135

58.     Peng Liu, Xin Xie, Miao Liu, Shuo Hu, Jinsong Ding, Wenhu Zhou*, A Smart MnO2 Doped Graphene Oxide Nanosheet for Enhanced Chemo-Photodynamic Combinatorial Therapy via Simultaneous Oxygenation and Glutathione Depletion, Acta Pharmaceutica Sinica B, 2021, 11, 823-834

59.     Yihua Yang, Lina Guo, Zhe Wang, Peng Liu, Xuanjun Liu, Jinsong Ding, Wenhu Zhou*, Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization, Biomaterials, 2021, 264, 120390

60.     Lina Guo, Yang Chen, Ting Wang, Yu Yuan, Yihua Yang, Xiaoli Luo, Shuo Hu, Jinsong Ding* and Wenhu Zhou*, Rational design of metal-organic frameworks to deliver methotrexate for targeted rheumatoid arthritis therapy, Journal of Controlled Release, 2021, 330, 119-131

61.     Ze Mi#, Lina Guo#, Peng Liu#, Yan Qi, Zhichao Feng, Jiahao Liu, Zhenhu He, Xiao Yang, Shengnan Jiang, Jianzhen Wu, Jinsong Ding, Wenhu Zhou*, and Pengfei Rong*, “Trojan Horse” Salmonella Enabling Tumor Homing of Silver Nanoparticles via Neutrophil Infiltration for Synergistic Tumor Therapy and Enhanced Biosafety, Nano letters, 2021, 21, 1, 414–423

62.     Yingcai Meng, Yuan Chen, Jiaojiao Zhu, Yan Qi, Jinsong Ding, Wenhu Zhou*, Polarity Control of DNA Adsorption Enabling Surface Functionalization of CuO Nanozyme for Targeted Tumor Therapy, Materials Horizons, 2021, 8, 972-986

63.     Mengchang Xu, Fenglin Liu, Wenhu Zhou*, Binsheng He, Songwen Tan*, Preparation and preliminary quality evaluation of aspirin/L-glutamate compound pellets, Journal of Materials Science: Materials in Medicine, 2021, 32:116

64.     Mengchang Xu, Wenhu Zhou*, Xuncai Chen, Ying Zhou, Binsheng He, Songwen Tan*, Analysis of the biodegradation performance and biofouling in a halophilic MBBR-MBR to improve the treatment of disinfected saline wastewater, Chemosphere, 2021, 269, 128716

65.     Hanyong Zhang, Wenhu Zhou*, Xuehui Zhan, Zhenxing Chi, Weiguo Li, Binsheng He, Songwen Tan*, Biodegradation performance and biofouling control of a halophilic biocarriers-MBR in saline pharmaceutical (ampicillin-containing) wastewater treatment, Chemosphere, 2021, 263, 127949

66.     Taoli Sun, Wenqun Li, Xiaoliang Tong, Xinyi Liu, Wenhu Zhou*, Xanthohumol attenuates isoprenaline-induced cardiac hypertrophy and fibrosis through regulating PTEN/AKT/mTOR pathway, European Journal of Pharmacology, 2021, 891, 15, 173690

67.     Peng Liu, Xuanjun Liu, Yan Cheng, Shenghui Zhong, Xinyi Shi, Shengfeng Wang, Jinsong Ding, Wenhu Zhou*, Core-Shell Nanosystems for Self-Activated Drug-Gene Combinations against Triple-Negative Breast Cancer, ACS Appl. Mater. Interfaces, 2020, 48, 53654-53664

68.     Yunbo Nie, Dan Li, Ying Peng, Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, Metal Organic Framework Coated MnO2 Nanosheets Delivering Doxorubicin and Self-activated DNAzyme for Chemo-gene Combinatorial Treatment of Cancer, International Journal of Pharmaceutics, 2020, 585, 1195

69.     Ying Peng, Peng Liu, Yingcai Meng, Jinsong Ding* and Wenhu Zhou*, Nanoscale Copper(II)-Diethyldithiocarbamate Coordination Polymer as Drug Self-delivery System for Highly Robust and Specific Cancer Therapy, Molecular Pharmaceutics, 2020, 8, 2864-2873

70.     Miao Liu, Ying Peng, Yunbo Nie, Peng Liu, Shuo Hu, Jinsong Ding* and Wenhu Zhou*, Co-delivery of doxorubicin and DNAzyme using ZnO@polydopamine core-shell nanocomposites for chemo/gene/photothermal therapy, Acta Biomaterialia, 2020, 110, 242-253

71.     Peng Liu, Xin Xie, Xinyi Shi, Ying Peng, Jinsong Ding and Wenhu Zhou*, Oxygen-Self-Supplying and HIF-1α-Inhibiting Core−Shell Nanosystem for Hypoxia-Resistant Photodynamic Therapy, ACS Appl. Mater. Interfaces 2019, 11, 48261−48270

72.     Liang Li, Yingcai Meng, Ling Li, Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, A Tetrahedral DNA Nanoflare for Fluorometric Determination of Nucleic Acids and Imaging of MicroRNA Using Toehold Strands, Microchimica Acta, 2019, 186, 824

73.     Yang Yihua, Wang Zhe, Peng Ying, Jinsong Ding* and Wenhu Zhou*, A Smart pH-Sensitive Delivery System for Enhanced Anticancer Efficacy via Paclitaxel Endosomal Escape, Frontiers in Pharmacology, 2019, DOI: 10.3389/fphar.2019.00010

74.     Xiaoli Luo, Xin Xie, Yingcai Meng, Taoli Sun, Jinsong Ding* and Wenhu Zhou*, Ligands dissociation induced gold nanoparticles aggregation for colorimetric Al3+ detection, Analytica Chimica Acta, 2019, 1087, 9, 76-85

75.     Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, An aptamer-tethered, DNAzyme-embedded molecular beacon for simultaneous detection and regulation of tumor-related genes in living cells, Analyst, 2019, 144, 5098-5107

76.     Liu Peng, Guo Binbin, Wang Shengfeng, Jinsong Ding* and Wenhu Zhou*, A thermo-responsive and self-healing liposome-in-hydrogel system as an antitubercular drug carrier for localized bone tuberculosis therapy, International Journal of Pharmaceutics, 2019, 558, 101-109

77.     Yang Chen, Cejun Yang, Juan Mao, Haigang Li, Ying, Jinsong Ding* and Wenhu Zhou*, Spermine Modified Polymeric Micelles with pH-Sensitive Drug Release for Targeted and Enhanced Antitumor Therapy, RSC Advances, 2019, 9, 11026-11037

78.     Yingcai Meng, Peng Liu, Wenhu Zhou*, Jinsong Ding*, Juewen Liu, Bioorthogonal DNA Adsorption on Polydopamine Nanoparticles Mediated by Metal Coordination for Highly Robust Sensing in Serum and Living Cells, ACS Nano, 2018, 12, 9070-9080

79.     Peng Liu, Shengfeng Wang, Xuanjun Liu, Jinsong Ding* and Wenhu Zhou*, Platinated graphene oxide: A nanoplatform for efficient gene-chemo combination cancer therapy, European journal of pharmaceutical sciences, 2018, 121, 319-329

80.     Binbin Guo, Yuqiao Zhang, Shengfeng Wang, Jinsong Ding and Wenhu Zhou*, The pharmacokinetics of morphine and codeine in human plasma and urine after oral administration of Qiangli Pipa Syrup, Journal of forensic science, 2018, 63, 1221-1228

81.     Shengfeng Wang, Chuantong Zhao, Peng Liu, Zhe Wang, Jinsong Ding* and Wenhu Zhou*, Facile construction of dual-targeting delivery system by using lipid capped polymer nanoparticles for anti-glioma therapy. RSC Advances, 2018, 8, 444–453

82.     Wenhu Zhou* and Juewen Liu*, "Multi-metal-dependent nucleic acid enzymes", Metallomics, 2018, 10, 30-48

83.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Splitting a DNAzyme enabling Na+-dependent FRET signal from the embedded aptamer", Organic & Biomolecular Chemistry, 2017, 15, 6959-6966

84.     Wenhu Zhou, Runjhun Saran, Jinsong Ding and Juewen Liu*, "Two Completely Different Mechanisms for Highly Specific Na+ Recognition by DNAzymes", ChemBioChem, 2017, 18, 1828-1835

85.     Wenhu Zhou, Runjhun Saran and Juewen Liu*, "Metal Sensing by DNA", Chemical Reviews, 2017, 117, 8272–8325

86.     Wenhu Zhou, Runjhun Saran, Po-Jung Jimmy Huang, Jinsong Ding and Juewen Liu*, "An Exceptionally Selective DNA Cooperatively Binding Two Ca2+ Ions", ChemBioChem, 2017, 18, 518-522.

87.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Theranostic DNAzymes", Theranostics, 2017, 7, 1010-1025

88.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "2-Aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver", Biosensors & Bioelectronics, 2017, 87, 171-177

89.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A highly specific sodium aptamer probed by 2-aminopurine for robust Na+ sensing", Nucleic Acids Research, 2016, 44, 10377-10385

90.     Wenhu Zhou, Tianmeng Yu, Mahsa Vazin, Jinsong Ding and Juewen Liu*, "Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis", Inorganic Chemistry, 2016, 55, 8193–8200

91.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence", ChemBioChem, 2016, 17, 1563–1570

92.     Wenhu Zhou, Mahsa Vazin, Tianmeng Yu Jinsong Ding and Juewen Liu*, "In Vitro Selection of Chromium-Dependent DNAzymes for Sensing Cr(III) and Cr(VI)", Chemistry, a European Journal, 2016, 22, 9835-9840

93.     Wenhu Zhou, Yupei Zhang, Jinsong Ding* and Juewen Liu*, "In Vitro Selection in Serum: RNA-Cleaving DNAzymes for Measuring Ca2+ and Mg2+", ACS Sensors, 2016, 1, 600-606

94.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "An Efficient Lanthanide-Dependent DNAzyme Cleaving 2’-5’ Linked RNA", ChemBioChem, 2016, 17, 890-894

95.     Wenhu Zhou, Runjhun Saran, Qingyun Chen, Jinsong Ding and Juewen Liu*, "A New Na+-Dependent RNA-Cleaving DNAzyme with over 1000-fold Rate Acceleration by Ethanol", ChemBioChem, 2016, 17, 159-163

96.     Wenhu Zhou, Yupei Zhang, Po-Jung Jimmy Huang, Jinsong Ding, and Juewen Liu*, "A DNAzyme requiring two different metal ions at two distinct sites", Nucleic Acids Research, 2016, 44, 354-363

97.     Wenhu Zhou, Jinsong Ding* and Juewen Liu*, "A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold", Chemical Communications, 2015, 51, 12084-12087

98.     Wenhu Zhou, Qingyun Chen, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "DNAzyme Hybridization, Cleavage, Degradation and Sensing in Undiluted Human Blood Serum", Analytical Chemistry, 2015, 87, 4001–4007

99.     Wenhu Zhou, Feng Wang, Jinsong Ding* and Juewen Liu*, "Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles", ACS Applied Materials & Interfaces, 2014, 6, 14795-14800

100. Wenhu Zhou, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "Aptamer-based biosensors for biomedical diagnostics", Analyst, 2014, 139, 2627-2640

101. Wenhu Zhou, Yanbin Zhou, Jianping Wu, Zhenbao Liu, Huanzhe Zhao, Juewen Liu*, and Jinsong Ding*. "Aptamer-nanoparticle bioconjugates enhance Intracellular delivery of vinorelbine to breast cancer cells", Journal of Drug Targeting, 2014, 22(1): 57-66

102. Wenhu Zhou, Shiying He, Yijun Yang, Dan Jian, Xiang Chen*, and Jinsong Ding*," Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma”, Drug development and industrial pharmacy, 2015, 41 (7), 1109-1119

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