教育经历：
本硕博均毕业于中南大学湘雅药学院，博士期间获国家留学基金委资助赴加拿大滑铁卢大学进行联合培养，获湖南省优秀博士学位论文。
工作经历：历任中南大学湘雅药学院药剂学系主任，现任湘雅药学院副院长。
研究领域：新型药物制剂、皮肤医用医疗器械与化妆品研究、药食同源制剂技术开发
招生方向：药学（药剂学）；生物医药
社会兼职
任Exploration杂志科学编辑，Acta Pharm. Sin. B, Asian J. Pharm. Sci., Chin. Chem. Lett., Chin. J. Cancer Res.杂志青年编委，肿瘤药学杂志编委。任中国药学会药剂专委会青年委员，中国颗粒学会青年理事，湖南省肿瘤药物研究与转化专委会副主任委员，湖南省药学会药剂专委会委员。
人才项目及获奖：
湖南省科技人才托举工程，年轻优秀科技人才，湖南省科协，2020年
湖南省优秀青年基金，肿瘤药剂学，湖南省科技厅，2021年
湖湘青年英才，湖南省科技厅，2021年
医学学科青年骨干人才，湖南省卫生健康委，2023年
湖南省自然科学二等奖（排名第一）
指导大学生创新创业大赛国家级奖项6项，省级奖项5项（互联网+，挑战杯等）
科研成果：
Ø 主持科研项目：
纵向国家级项目
国家自然科学基金，可突破免疫屏障的“隐形”沙门氏菌联合放疗免疫增敏用于宫颈癌的治疗研究
国家自然科学基金，基于功能核酸串联的诊疗一体化探针的构建与应用研究
国家自然科学基金，以黑色素瘤外泌体高皮肤渗透及免疫调节作用为启发的抗银屑病仿生制剂研究
横向项目
校企合作科研项目30余项
代表性产品转化与上市
1. 透明质酸锌：HA-ZnO，商品名“透以因”，是一款以透明质酸仿生矿化稳定氧化锌纳米粒的祛痘控油创新原料，具备选择性抑菌、控油、抗炎、促愈四重功效，可靶向解决痘痘肌出油、泛红与修护难题；围绕核心制备工艺已申请发明专利3项（一种改性ZnO纳米粒的制备方法及应用2024113111631、一种ZnO纳米颗粒的制备方法2024113111627、一种氧化锌纳米粒及其制备方法和祛痘、抗炎、控油应用2024116383040），核心技术发表于国际权威期刊Journal of Controlled Release（2025，IF 10.5，中科院一区），并配套原料介绍、TDS、MSDS、COA及检测方法、生产工艺、第三方测试及人体功效评价（7天皮损减少38.02%、无不良反应）等全套14项合规资料；以此为核心的控油祛痘美肌面膜、控油祛痘舒润精华液、舒润清透隔离乳、背部祛痘喷雾4款化妆品已完成备案并上市销售（湘G妆网备字2025000128–0130、2025001863），实现“专利—论文—原料—产品—市场”全链条转化。
2. 甘草酸-锌：GA-Zn，商品名“辛甘因”，即锌甘草酸超分子，是锌离子（Zn⟡⁺）与甘草酸（GA）基于金属有机配位的超分子自组装技术所制备得来，是一款兼具强大抗氧化能力、高效俘获自由基、抗炎和促进屏障修复功效的创新原料；核心技术发表于国际期刊Journal of Controlled Release（2026，IF 10.5，中科院一区）；配套原料介绍、TDS、MSDS、COA及检测方法、生产工艺、第三方测试及人体功效评价（有效抗组胺、30名人体均验证了优异的保湿修护功效）等全套14项合规资料；该原料已完成备案并上市销售，具备完整的合规与产业化基础。
3. 壬二酸纳米晶：商品名“纴光因”，是一款基于pH调控纳米化策略构建的壬二酸纳米晶祛痘创新原料，具备抑菌、抗炎、修复、重塑四重功效，可靶向解决痤疮丙酸杆菌感染、炎症泛红，皮肤屏障受损难题。围绕核心制备工艺已授权发明专利1项（壬二酸纳米晶及其制备方法和在制备祛痘外用制剂中的应用2026110562737），相关数据已投稿至IJP杂志，并配备原料介绍、TDS、MSDS、COA及检测方法、生产工艺，等合规资料，后续相关资料将陆续补充，实现“专利—论文—原料—产品—市场”全链条转化。
4. 铜肽自组装纳米粒，商品名“极光因”，是一款以铜离子与三肽-1配位自组装、透明质酸稳定、抗坏血酸温和还原构建的铜簇抗衰原料，通过“清除自由基—抑制胶原降解—促进蛋白新生”三维协同机制从源头应对光老化。同等含铜量下，它在抗氧化、促胶原、抗降解、抗衰老、促修复、真皮靶向递送六大维度全面优于经典蓝铜胜肽（GHK-Cu），其中I型胶原恢复量约为其1.6倍，真皮层铜蓄积量约为其1.7倍，且抗酶解稳定性与高浓度耐受性同样优异；斑马鱼光老化模型进一步验证其可逆转紫外线损伤、促进胶原蛋白与弹性蛋白生成，并显著降低游离铜急性毒性。目前已完成原料介绍、TDS、MSDS、COA、检测方法、生产工艺等全套合规资料规整，正推进备案。
5. 锌肽自组装纳米粒，商品名 “凝辛茵”，创新采用MOF金属有机框架超分子自组装纳米递送技术，是一款以透明质酸稳定的肌肽锌纳米粒抗糖化抗衰老创新原料，具备抑制晚期糖基化终末产物生成、清除过量活性氧、抗炎、修护胶原基质四重功效，可解决肌肤糖化发黄、暗沉松弛、胶原流失等难题；目前针对该纳米原料的核心制备工艺，已完成专利技术方案梳理，发明专利申报工作正在推进当中，相关实验数据与科研成果正在整理，后续拟投稿国际权威期刊发表；现已完成全套原料技术文件建设，配套原料介绍、TDS、MSDS、COA及检测方法、生产工艺、第三方测试及人体安全性评价（无不良反应）等全套14项合规资料；依托成熟的原料技术资料，后续将开展下游护肤产品开发，逐步完成从实验室技术向美妆市场落地的全链条转化。
6. 透明质酸胶态硫，商品名 “琉萃因”，是一款以透明质酸仿生矿化稳定超分子硫单质的祛痘控油创新原料。其以透明质酸为仿生模板矿化成型，将硫单质稳定为均一分散的超分子，突破传统胶态硫易团聚沉降、理化稳定性差与刺激性偏高的应用瓶颈；通过选择性抑菌、控油、抗炎、促愈、预防痘印五维机制协同起效，靶向干预痘痘肌出油、泛红与屏障修护三大难题。与传统胶态硫相比，琉萃因在物理化学稳定性与生物安全性上显著提升，抗痤疮丙酸杆菌活性提高超10倍。鸡胚绒毛尿囊膜模型及人体、兔皮肤斑贴试验表明，该原料安全温和，未见刺激性反应。目前已完成原料介绍、TDS、MSDS、COA、检测方法、生产工艺等全套合规资料规整，正推进原料备案。
7. 5-羟色胺银纳米粒，商品名“优银护”，是一种创新性pH响应核壳结构的纳米银材料。其利用5-羟色胺在碱性条件下的自氧化聚合，实现银离子的原位还原并形成聚羟色胺包覆层，该壳层在感染部位的弱酸性环境下快速降解，释放银离子，从而增强局部抗菌活性；而在正常细胞微环境中则稳定存在，减少银离子泄露，显著降低细胞毒性。传统纳米银在抗菌的过程中，其对哺乳细胞的毒性制约着创面愈合进程，该核壳纳米银的高效抗菌、组织修复、免疫调控多重机制，实现了"精准抗菌-微环境重编程-自噬激活"的多级协同治疗。围绕核心制备工艺已申请发明专利2项（一种多功能银纳米粒及其制备方法与应用2022103450743、一种多功能胶态银在促进伤口愈合、预防瘢痕形成中的应用2025106041200），核心技术发表于国际权威期刊《Advanced Functional Materials》（中科院一区TOP期刊，影响因子19）。以此原料为核心，备案3款消毒产品（皮肤消毒液、抗菌凝胶、抑菌洗液），打通原料的产品转化路径。
Ø 授权发明专利：
以第一发明人授权国家发明专利15项，已完成转让专利10项，部分专利列举如下：
1. 纳米配位聚合物及其制备方法和应用，ZL 201910805848.4，排名第一，授权公告日：2020年06月23号
2. 一种抑制活化巨噬细胞增殖的聚合物/银活性键合物及其制备和应用，ZL 201910374069.3，排名第一，授权公告日：2020年06月16号
3. 一种酸性环境中可降解的表面涂层及其制备方法与应用，ZL 202010675017.2，排名第一，授权公告日：2021年04月13日
4. 一种电荷可控的聚合物材料及其制备方法与应用，ZL 202010676053.0，排名第一，授权公告日：2021年07月23日
5. 一种DNA/纳米复合物及其制备方法与应用，ZL 202110041560.1，排名第一，授权公告日：2022年06月28日
6. 包载甲氨蝶呤的铁-鞣酸配合物及其制备方法和应用，ZL202010903340.0，排名第一，授权公告日：2022年08月12日
7. 一种具有粘液渗透的核酸纳米载体及其制备方法与应用，ZL202111304068.5，排名第一，授权公告日：2022年11月25日
8. 雄黄纳米粒的制备方法和应用，ZL202010887138.3，排名第一，授权公告日：2022年11月25日
9. 一种多酚自聚纳米粒及其制备方法与应用，ZL 2021 1 1433444.0，排名第一，授权公告日：2024年05月03日
10. 一种基于DNAzyme调控基因编辑的方法，ZL 202111160432.5，排名第一，授权公告日：2022年03月04日
11. 一种用于靶向治疗血栓性疾病的纳米颗粒及其制备方法和应用，ZL 2023 1 0165897.2，排名第一，授权公告日：2024年06月18日
12. 一种多功能靶向腹主动脉瘤的纳米粒及其制备方法与应用，ZL 2024 1 1207867.4，排名第一，授权公告日：2026年02月06日
13. 壬二酸纳米晶及其制备方法和在制备祛痘外用制剂中的应用，ZL 2026 1 1056273.7，排名第一，授权公告日：2026年9月11日
代表性论文
以（共同）通讯作者身份在Adv. Funct. Mater., ACS Nano, Adv. Sci.等国际权威期刊发表SCI论文100余篇，总被引12000余次，H指数62；高被引论文25篇，热点论文6篇；连续三年入选全球前2%顶尖科学家榜单，科睿唯安2025、2026年度“全球高被引科学家”，部分论文列举如下：
1. Ouyang Qin, Gao Runwei, Li Sisi, Liang Junhao, Li Pei,Zhou Wenhu*. Multifunctional selenium nanoplatforms for synergistic ferroptosis inhibition and immune microenvironment remodeling in oral mucositis.BIOMATERIALS. 2026,332:124147
2. Tian Li, Huang Jiaxin, Xu Youwei, Zhao Panpan, Li Yankun, Wei Xiaomin, Li Mingdong, Jiang Shiyin, Huang Qianping, Xu Yi, Lu Caiyang, Ding Jinsong,Zhou Wenhu*, Gao Xiang*. Dual-functional tea polyphenol-serotonin nanoparticles for integrated inflammation suppression and mucosal repair in inflammatory bowel disease.BIOMATERIALS.2026,331:124076
3. Yao Ying, Tian Juan, Zhang Ran, Liu Ping, Gao Xiang*,Zhou Wenhu*, Luo Longlong*. Nanobody-based radiotracers in nuclear medicine: Advances, challenges, and future perspectives.CHINESE CHEMICAL LETTERS. 2026,37(6)111517.
4. Duan Yubei; Huang Jiaxin; Huang Tianping; Yang Kaige; Qi Liwen; Yu Baohua; Li Fanping; Yin Maosheng; Zhao Lei; Chai Zhenghua; Liang Weihua; Zhang Haijun; Fei Jing; Ding Jinsong; Luo Chenghua*;Zhou Wenhu*; Hu Jianming*. Breaking the oncogene-immune suppression cycle through dual HER2 silencing and innate immune activation by biomineralized DNA nanocomplexes.JOURNAL OF CONTROLLED RELEASE.2026,395:115009
5. Li Qingnian, Wang Jing, Miao Jie, Liu Dexian, Xiong Wanying, Xiao Bo,Zhou Wenhu*. A Monocyte-Targeted Nanoplatform for Phagocytosis Activation and Ferroptosis Inhibition in Intracerebral Hemorrhage.SMALL.2026,202514883
6. Al-Azzani Hamdi; Vithran Djandan Tadum Arthur; Batool Syeda Sundas; Alshabi Malek Mohammed Ali;Zhou Wenhu*; Mao Xiaoqiang*. Aptamer-Functionalized Nanocarriers for Bone and Joint Diseases: Engineering Design Rules and Translational Roadmap.SMALLSCIENCE. 2026,6(5):e70294
7. Li Qingnian, Zhang Ye, Zhu Jiaojiao, Xu Linyong, Wang Shengfeng*, Yang Minghua*,Zhou Wenhu*. Nanocluster-mediated co-delivery of silver ions and fluconazole enhances antifungal therapy for urinary tract infections via energy metabolism modulation.CHEMICAL ENGINEERING JOURNAL.2026,534:175128
8. Miao Jie; Wang Jing;Zhou Wenhu*; Guo Junhong*. Small-molecule PCSK9 inhibition enhances BBB amyloid-beta clearance and suppresses microglial inflammation in Alzheimer's disease models.SCIENTIFIC REPORTS. 2026,16(1):15780
9. Cui Yanhui, Wang, Xueqin, Lu, Caiyang, Ran, Liling, Guo, Zirui, Yao, Jiayu, Yu, Tian, Liu, Xuanxi, Li, Fang, Li, Changqi, Meng, Yingcai*, Zhou, Wenhu*. Treating acute respiratory distress syndrome with a multifaceted nanomedicine: Inhibition of PANoptosis and enhancement of lung barrier integrity.MATERIALS TODAY BIO.2026,36:102748
10. Wei Yaling, He Jiaming, Ding Jinsong, Lu Caiyang,Zhou Wenhu*, Deng Xinjie*. Zinc for skin diseases treatment: Progress and prospects in advanced delivery systems.CHINESE CHEMICAL LETTERS. 2025,37(10):112425
11. Liang Junhao, Yao Haobo, Feng Yinghui, Shu Xin, Zheng You*, Gao Xiang*,Zhou Wenhu*. Advances in organoids for drug development: From discovery to delivery.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY.2026,127(1):108876
12. Ouyang, Qin; Xiang, Shiqi; Guo, Yupeng; Yuan, Jun; Chen, Pan; Tang, Qishun; Hu, Chunhui; Zhou, Wenhu*; Huang, Shu*. Modernizing Traditional Mineral Medicine: Pyrolusite-Derived MnO2 Nanoplatform for Osteo-Angio-Immunomodulatory Bone Repair.ACS nano. 2026, 20(32):22452-22474
13. Li Sujing, Wang Sisi, Li Yanbin, Huang Yinting, Zhu Qubo, Mei Lin,Zhou Wenhu*, Xie Nuli*. Precise Disease Analysis and Diagnosis Driven by DNA Circuits: From Single Target to Multiple Targets, From Simple to Intelligent.SMALL.2026,75224
14. Tan Yutao, Qin Xinyuan, Chen Qisheng,Zhou Wenhu*, Zheng Caixia*. Functional ionic liquids for enhanced transdermal drug delivery: Recent advances and future perspectives.COLLOIDS AND SURFACES B-BIOINTERFACES.2026, 268(2):116082
15. Li Yanhui*, Zhou, Wenhu*. Enzyme conjugated magnetic nanocomposite hydrogel based on chitosan as a green fluorescent cholesterol biosensor.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES.2026, 377:153327
16. Li Yanhui, Zhou, Wenhu*. Liposomal nanocarriers in precision oncology: Advances and prospects.CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY.2026,221:105236
17. Li Yanhui, Zhou, Wenhu*. Nanoparticle-driven macrophage polarization as a therapeutic strategy for chronic diabetic wounds.INTERNATIONAL IMMUNOPHARMACOLOGY.2026, 186:117161
18. Wang Ying, Xiong Wanying, Xu Yiyan, Yang Nan, Zheng Huige, Zhao Qian, Liang Xiaojing, Yin Huishuang, Zhang Yunyan*,Zhou Wenhu*, Fan Liangsheng*. Nano-immunotherapy combining PD-L1 blockade with Ca2+-mediated immune activation.CHEMICAL ENGINEERING JOURNAL. 2026, 540:177487
19. Wang Dan, Wei Yaling, Xu Shenming, Long Daijing, Li Pei, Li Yankun, Zhu Jun,Zhou Wenhu*. A zinc-glycyrrhizic acid hydrogel alleviates atopic dermatitis by targeting the TLR4/NLRP12-driven PANoptosis axis.JOURNAL OF CONTROLLED RELEASE.2026, 397:115142
20. Wei Ziye, Zhuo Shijie, Zhang Yixin, Wu Lianlian, Gao Xiang*, He Song*, Bo Xiaochen*,Zhou Wenhu*. Machine learning reshapes the paradigm of nanomedicine research.ACTA PHARMACEUTICA SINICA B.2026, 16(7):4024-4050 Ke Li, Jieru Yang, Ying Peng, Huiwen Zheng, Zhizhan Fu, Meiying Li,Wenhu Zhou*, Guofeng Yu, Advances in metal ion-mediated macromolecular drug delivery,International Journal of Pharmaceutics, 2026, 689, 126501
21. Hamdi Al-Azzani, Djandan Tadum Arthur Vithran, Djandan Tadum Arthur Vithran, Hanane Alioua, Hanane Aliouat,Wenhu Zhou*,Xiaoqiang Mao*, Precision bacterial immunotherapy: an integrated mechanistic taxonomy and translational roadmap against antimicrobial resistance,Front. Immunol., 2025, doi: 10.3389/fimmu.2025.1675682
22. Li, Ke; Yang, Jieru; Peng, Ying; Zheng, Huiwen; Fu, Zhizhan; Li, Li, Meiying;Zhou, Wenhu*; Yu, Guofeng*. Advances in metal ion–mediated macromolecular drug delivery,International Journal of Pharmaceutics, 2026, 689, 20, 126501
23. Hui Wang, Cui Tang, Hanfeng Zhang, Lina Guo, Chan Zou, Shengting Zhang, Jinlong Liu, Qianping Huang, Yujun Liu,Wenhu Zhou*,Guoping Yang*, Xiang Gao*, A biocompatible tea polyphenol nanoplatform for efficient cytosolic delivery of protein therapeutics,Journal of Controlled Release, 2025, 388, 114347
24. Juzuo Zhang, Fenfang Zhang, Shunqing Wang, Pan Li, Xiang Jian, Lin Shu, Naxin Zhang,Wenhu Zhou*,Junfei Xu*, Excessive Use of Polygonatum sibiricum Causes No Acute Lethality but Induces Multiple Toxic Effects in Mice,J Appl Toxicol.2025
25. Liang Zhang, Ming Zhou, Chenxi Lu, Pinnan Zhao, Ning Shi, Yangyihua Zhou, Chaoyan Yao, Xuechen Yang, Juan Tian, Jie Wang, Yaowei Ma, Qianping Huang, Can Xu, Peixun Gao,Wenhu Zhou*,Shuo Hu*, Longlong Luo*, A high-affinity CEA-targeted nanobody for 68Ga PET imaging and 177Lu-based radioisotope therapy: preclinical and first-in-human evaluation,J Nanobiotechnol2025, 23, 734
26. Yuanzheng Chen, Ying Yao, Jie Fu, Yi Xu, Yujie Lin, Jinsong Ding,Wenhu Zhou*,Jianfeng Yang*Mingdong Lu*, Hemin-Loaded Nanoparticles Improve Iron Supplementation and Gut Microbiota Balance in Iron-Deficiency Anemia Therapy,ACS Appl. Mater. Interfaces2025, 17, 46, 63198–63212
27. Shengmei Wang, Ding Ma,Minghua Yang, Ye Zhang, Shengfeng Wang,Wenhu Zhou*,Arsenic trioxide-based nanoparticles for enhanced chemotherapy by activating pyroptosis,Acta Pharmaceutica Sinica B, 2025, 15, 11, 6001-6018
28. Hyaluronic acid-ornithine crosslinked hydrogel as a superior 3D culture platform for high-quality exosome production in advanced wound healing,Stem Cell Res Ther, 2025,16, 518
29. Yuanzheng Chen, Qubo Zhu, Yanbin Zhou,Wenhu Zhou*,Yan Chen*, Multifunctional nanomedicine targeting the 'seed-and-soil' of hair follicles via simultaneous alleviation of oxidative stress and activation of autophagy for androgenetic alopecia therapy,Materials Today Bio, 2025, 102145
30. Jiaojiao Zhu, Tiao Wen, Yunxiao Ma, Qingya Zeng, Yilan Lin, Yutian Liu, Shanshan Chen, Qiang Wang* andWenhu Zhou*,Enhanced Xanthium-Inspired ZnO for Precision Antibacterial Therapy and Regeneration of Infected Wounds,Adv. Healthcare Mater,2025, 2501009
31. Jiaojiao Zhu, Qingya Zeng, Yutian Liu, Yilan Lin, Ding Ma, Tiao Wen, Pei Li, andWenhu Zhou*,Smart Nanosilver Strikes Twice: Precision Bacteria Killing Meets Autophagy-Boosted Healing for Infected Wounds,Adv. Funct. Mater.,2025, 2507797
32. Jiaojiao Zhu, Tiao Wen, Yunxiao Ma, Qingya Zeng, Pei Li andWenhu Zhou*, Biomimetic Hyaluronic Acid-Stabilized Zinc Oxide Nanoparticles: Selective Antibacterial Activity and Multi-Mechanistic Skin Repair for Acne Treatment,Journal of Controlled Release, 2025, 382, 10, 113754
33. Qingya Zeng#, Jiaojiao Zhu#, Zongyun He, Hong Qin,Wenhu Zhou*,Fangqi Hua*, Jin Yang*,Context-dependent roles of 5-HT and its receptors in tumor growth and wound healing: Mechanisms and therapeutic implications,Chin J Cancer Res, 2025, 37, 2: 268-288
34. Jieru Yang#,Jiaojiao Zhu#, Shan Lu, Hong Qin,Wenhu Zhou*,Transdermal Psoriasis Treatment Inspired by Tumor Microenvironment-Mediated Immunomodulation and Advanced by Exosomal Engineering,Journal of Controlled Release, 2025, 382, 10, 113664
35. Hanane Aliouat, Detian Zhang, Lanyuan Peng, Jiaxin Huang, Hongshi Cheng, Jiaojiao Zhu, Xiang Chen, Nuli Xie*,Wenhu Zhou*,Shuang Zhao*, Targeted DNA Nanomachine Enables Specific miRNA-Responsive Singlet Oxygen Amplification for Precise Cutaneous Squamous Cancer Therapy,Adv. Sci.2025, 12, 2415296
36. Jiaxin Huang, Jieru Yang, Yuanying Yang, Xiaofeng Lu, Juan Xu, Shan Lu, Hong Pan,Wenhu Zhou*,Wenqun Li*, Songwen Chen*, Mitigating Doxorubicin-Induced Cardiotoxicity and Enhancing Anti-Tumor Efficacy with a Metformin-Integrated Self-Assembled Nanomedicine,Adv. Sci.2025, 2415227
37. Ying Yao, Yuanzheng Chen, Jie Fu, Jinsong Ding,Wenhu Zhou*,Xinyi Chen*, Xiuping Wan*,A metal-polyphenol network-based iron supplement with improved stability and reduced gastrointestinal toxicity for iron deficiency anemia therapy,Materials Today Bio, 2025, 31, 101598
38. Peng Liu+, Ming Zhou+, Zhisheng Luo, Lu Hao, Jessica C. Hsu, Weibo Cai,Wenhu Zhou*,Shuo Hu*, A 177Lu-nucleotide coordination polymer-incorporated thermosensitive hydrogel with anti-inflammatory and chondroprotective capabilities for osteoarthritis treatment,Biomaterials, 2025, 317, 123098
39. Xiangcheng Zhao+, Peng Yan+, Hailong Zhang,Wenhu Zhou*,Jinsong Ding*, A novel levodopa-carbidopa three-layer gastroretentive tablet for improving levodopa pharmacokinetics,European Journal of Pharmaceutics and Biopharmaceutics, 2025, 207, 114633
40. Cui Tang, Hui Wang, Lina Guo, Yimin Cui, Chan Zou, Jianming Hu, Hanyong Zhang, Guoping Yang*,Wenhu Zhou*,Multifunctional Nanomedicine for Targeted Atherosclerosis Therapy: Activating Plaque Clearance Cascade and Suppressing Inflammation,ACS Nano2025, 19, 3, 3339–3361
41. Peng Liu+, Jia Guo+, Zuozhong Xie+, Yusheng Pan, Benliang Wei, Ying Peng, Shuo Hu, Jinsong Ding, Xiang Chen*, Juan Su*, Hong Liu*,Wenhu Zhou*,Co-Delivery of aPD-L1 and CD73 Inhibitor Using Calcium Phosphate Nanoparticles for Enhanced Melanoma Immunotherapy with Reduced Toxicity,Adv. Sci.2024, 2410545
42. Jiahao Liu+, Qingnian Li+, Hanyu Tu+, Jie Feng, Xiaofei Fan, Ze Mi, Hongpei Han, Xiaoqian Ma, Qi Liang, Zheng Zhang, Hongshuai Hou*, Pengfei Rong*,Wenhu Zhou*,Bismuth/manganese-doped carbon dots in calcium phosphate matrix: Dynamic conformational nanoparticles enhancing tumor accumulation, deep penetration, and radiosensitivity,Chemical Engineering Journal, 2025, 504, 158683
43. Jieru Yang#, Huanmin Kang#, Yingyi Liu, Yan He*,Wenhu Zhou*,Harnessing Tumor Cell-Derived Exosomes for Immune Rejection Management in Corneal Transplantation,Adv. Sci.2024, 2409207
44. Lingjiao Li, Chengyao Feng, Wenchao Zhang, Lin Qi, Binfeng Liu, Hua Wang, Chenbei Li, Zhihong Li, Chao Tu*,Wenhu Zhou*,Mitigation of Cisplatin-Induced Nephrotoxicity and Augmentation of Anticancer Potency via Tea Polyphenol Nanoparticles’ Codelivery of siRNA from CRISPR/Cas9 Screened Targets,ACS Appl. Mater. Interfaces2024, 16, 44, 59721–59737
45. Jiahao Liu, Peng Liu, Junhong Duan, Qiongxuan Xie, Jie Feng, Hongpei Tan, Ze Mi, Ying Li, Yunjie Liao, Pengfei Rong*,Wenhu Zhou*,Xiang Gao*, Macrophages-mediated tumor accumulation and deep penetration of bismuth/manganese biomineralized nanoparticles for enhanced radiotherapy,Chinese Chemical Letters, 2024, 35, 109632
46. Yujie Fan, Yangqin Ou, Ting Xiao, Ziye Wei, LiLing Zhu, Chenghao Zhu, Yiran Ma, Shuangquan Qu*,Wenhu Zhou*,Coordination-Driven Nanomedicine Mitigates One-Lung Ventilation-Induced Lung Injury via Radicals Scavenging and Cell Pyroptosis Inhibition,Small2024, 2401056
47. Ying Zhou, Yunxiao Ma, Jianwei Sheng, Yiran Ma, Jinsong Ding*,Wenhu Zhou*,Breaking Down Barriers in Drug Delivery by Stromal Remodeling Approaches in Pancreatic Cancer,Mol. Pharmaceutics2024, 21, 8, 3764–3776
48. Aiping Huang, Qingnian Li, Xinyi Shi, Junyi Gao, Yiran Ma, Jinsong Ding, Surong Hua*,Wenhu Zhou*,An iron-containing nanomedicine for inducing deep tumor penetration and synergistic ferroptosis in enhanced pancreatic cancer therapy,Materials Today Bio, 2024, 27, 101132
49. Shan Lu, Ze Mi, Peng Liu, Jinsong Ding, Yiran Ma, Jieru Yang*, Pengfei Rong*,Wenhu Zhou*,Repolarizing neutrophils via MnO2 nanoparticle-activated STING pathway enhances Salmonella-mediated tumor immunotherapy,J Nanobiotechnol, 2024 22, 443
50. Youwei Xu, Zhonghui Zheng, Qing Lin, Jiaxin Huang, Jinsong Ding,Wenhu Zhou*,Structure Determination and 3D ED/MicroED-Guided Synthesis of a New (S)-Ibuprofen–l-phenylalanine Co-Crystal,Cryst. Growth Des.2024, 24, 12, 4924–4929
51. Ming Zhou, Xiaoqin Yin, Bei Chen, Shuo Hu*,Wenhu Zhou*,A PET probe targeting polyamine transport system for precise tumor diagnosis and therapy,Asian Journal of Pharmaceutical Sciences, 2024, 19, 100924
52. Yingcai Meng, Jiaxin Huang, Jinsong Ding, Haiyan Zhou*, Yong Li*,Wenhu Zhou*,Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy,Materials Today Bio, 2024, 26, 101018
53. Ying Wang, Yiyan Xu, Jiayu Song, Xueting Liu, Sijia Liu, Nan Yang, Le Wang, Yujie Liu, Yiwei Zhao,Wenhu Zhou*,Yunyan Zhang*, Tumor Cell-Targeting and Tumor Microenvironment–Responsive Nanoplatforms for the Multimodal Imaging-Guided Photodynamic/Photothermal/Chemodynamic Treatment of Cervical Cancer,Int J Nanomedicine. 2024;19:5837-5858
54. Hui Wang, Cui Tang, Yuxia Xiang, Chan Zou, Jianming Hu, Guoping Yang*,Wenhu Zhou*,Tea polyphenol-derived nanomedicine for targeted photothermal thrombolysis and inflammation suppression,J Nanobiotechnol, 2024, 22, 146
55. Jing Wang, Nuli Xie, Shan Lu, Bo Xiao, Yangqin Ou, Qingnian Li, Dexian Liu,Wenhu Zhou*,CpG and Rutin Co-Loaded DNA Tetrahedra for Targeted Therapy of Intracerebral Hemorrhage: Synergistic Hematoma Clearance and Neuroinflammation Inhibition,Advanced Functional Materials, 2024, 2403469.
56. Jiaojiao Zhu, Lanyuan Peng, Shah Jehan, Haiyang Wang, Xiang Chen, Shuang Zhao, andWenhu Zhou*, Activable Photodynamic DNA Probe with an "AND" Logic Gate for Precision Skin Cancer Therapy,Research, 2024, DOI: 10.34133/research.0295
57. Xueming Xua, Yuanfeng Han, Jiali Deng, Shengfeng Wang, Shijie Zhuo, Kai Zhao,*Wenhu Zhou*,Repurposing disulfiram with CuET nanocrystals: Enhancing anti-pyroptotic effect through NLRP3 inflammasome inhibition for treating inflammatory bowel diseases,Acta Pharmaceutica Sinica B, 2024, 14 (6), 2698-2715
58. Xurui Gu, Kun Liu, Yixuan Deng, Bixiao Xiang, Lingyun Zhou, Wenjun Yin, Jiaxin Huang, Yingcai Meng, Dianke Li, Ruiman Que, Zhiyao Tang, Guangliang Zhou, Yifeng Wu, Yujie Huang,Wenhu Zhou*,Xiaocong Zuo*,A Renal-Targeted Gene Delivery System Derived from Spermidine for Arginase-2 Silencing and Synergistic Attenuation of Drug-Induced Acute Kidney Injury,Chemical Engineering Journal, 2024, 486, 150125
59. Yuanzheng Chen, Jiaojiao Zhu, Jinsong Ding, Wenhu Zhou, Recent progress of vaccines administration via microneedles for cancer immunotherapy,Chinese Chemical Letters, 2024, 35, 108706
60. Lina Guo, Jinsong Ding,Wenhu Zhou*,Harnessing bacteria for tumor therapy: Current advances and challenges,Chinese Chemical Letters, 2024, 35, 108557
61. Ying Peng, Peng Liu, Jinsong Ding,Wenhu Zhou*, Biomineralized nanomedicine for enhanced cancer therapy through in situ toxification and amplified Ca2+ overload,Chemical Engineering Journal, 2023, 475, 146277
62. Lina Guo, Jinsong Ding,Wenhu Zhou*, Converting bacteria into autologous tumor vaccine via surface biomineralization of calcium carbonate for enhanced immunotherapy,Acta Pharmaceutica Sinica B, 2023, 13(12): 5074–5090.
63. Jiaojiao Zhu+, Tiao Wen+, Shuangquan Qu, Qingnian Li, Biwu Liu, andWenhu Zhou*, G-quadruplex/Hemin DNAzyme-Functionalized Silver Nanoclusters with Synergistic Anti-Bacterial and Wound Healing Capabilities for Infected Wound Management,Small, 2023, 2307220
64. Lina Guo, Hao Chen, Jinsong Ding, Pengfei Rong, Ming Sun,Wenhu Zhou*, Surface engineering Salmonella with pH-responsive polyserotonin and self-activated DNAzyme for better microbial therapy of tumor,Exploration2023, 00, 20230017
65. Cui Tang, Hui Wang, Lina Guo, Chan Zou, Jianming Hu, Hanyong Zhang,Wenhu Zhou*, and Guoping Yang*, CpG Conjugated Silver Nanoparticle as Multifunctional Nanomedicine to Promote Macrophage Efferocytosis and Re-polarization for Atherosclerosis Therapy,ACS Appl. Mater. Interfaces2023, 15, 45, 52162–52179
66. Xiangcheng Zhao, Nuli Xie, Hailong Zhang,Wenhu Zhou*,and Jinsong Ding*, Bacterial Drug Delivery Systems for Cancer Therapy: “Why” and “How”,Pharmaceutics, 2023, 15(9), 2214
67. Hao Chen, Lina Guo, Jinsong Ding,Wenhu Zhou*,Yan Qi*,A General and Efficient Strategy for Gene Delivery Based on Tea Polyphenols Intercalation and Self-Polymerization,Advanced Science, 2023, 2302620.
68. Zhang, Hui; Wang, Laifa; Zhu, Bi; Yang, Yongping; Cai, Chuanhai; Wang, Xueqin; Deng, Ling; He, Binsheng; Cui, Yanhui*,Wenhu Zhou*,A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats,European Journal of Pharmacology, 2023, 951, 15, 175801
69. Liping Dong, Jinsong Ding, Lemei Zhu, Yujun Liu, Xiang Gao*,Wenhu Zhou*,Copper carbonate nanoparticles as an effective biomineralized carrier to load macromolecular drugs for multimodal therapy,Chinese Chemical Letters, 2023, 34, 108192
70. Yingcai Meng, Jiaxin Huang, Jinsong Ding, Bohua Yan, Yong Li*, Xiang Gao*,Wenhu Zhou*,Poly-thymine DNA templated MnO2 biomineralization as a high-affinity anchoring enabling tumor targeting delivery,Journal of Colloid and Interface Science, 2023, 637, 441-452
71. Shu Huang, Jun Yuan, Yong Xie, Kai Qing, Zeya Shi, Guanyu Chen, Jie Gao, Haoxiang Tan,Wenhu Zhou*,Targeting nano-regulator based on metal–organic frameworks for enhanced immunotherapy of bone metastatic prostate cancer,Cancer Nanotechnology, 2023, 14, 43
72. Aiping Huang,Wenhu Zhou*,Mn-based cGAS-STING activation for tumor therapy.Chin J Cancer Res2023; 35(1):19-43.
73. Hui Zhang†, Laifa Wang†, Yongping Yang, Chuanhai Cai, Xueqin Wang, Ling Deng, Binsheng He,Wenhu Zhou*and Yanhui Cui*, DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress,Frontiers in Pharmacology, 2023, DOI: 10.3389/fphar.2022.987293
74. Lingjiao Li†, Shengmei Wang† andWenhu Zhou*, Balance Cell Apoptosis and Pyroptosis of Caspase-3-Activating Chemotherapy for Better Antitumor Therapy,Cancers, 2023, 15, 26
75. Jia Guo+, Peng Liu+, Benliang Wei+, Ying Peng, Jinsong Ding, Hailun Zhang, Guanxiong Zhang, Juan Su*, Hong Liu*,Wenhu Zhou*, Xiang Chen*, Reversing the Negative Effect of Adenosine A1 Receptor-Targeted Immunometabolism Modulation on Melanoma by a Co-delivery Nanomedicine for Self-activation of anti-PD-L1 DNAzyme,Nano Today, 2023, 48, 101722
76. Xiaoxiong Xiao, Min Chen, Yuchen Zhang, Liang Li, Ying Peng, Junyu Li*andWenhu Zhou*, Hemin-incorporating DNA nanozyme enabling catalytic oxygenation and GSH depletion for enhanced photodynamic therapy and synergistic tumor ferroptosis,Journal of Nanobiotechnology, 2022, 20:410
77. Jiaojiao Zhu+, Ruimin Chang+, Benliang Wei, Yao Fu, Xiang Chen*, Hong Liu*, andWenhu Zhou*, Photothermal Nano-Vaccine Promoting Antigen Presentation and Dendritic Cells Infiltration for Enhanced Immunotherapy of Melanoma via Transdermal Microneedles Delivery,Research, 2022, DOI：10.34133/2022/9816272
78. Jiahao Liu#, Lina Guo#, Ze Mi, Liu Zhenguo, Pengfei Rong* andWenhu Zhou*, Vascular Bursts-Mediated Tumor Accumulation and Deep Penetration of Spherical Nucleic Acids for Synergistic Radio-Immunotherapy,Journal of Controlled Release, 2022, 348, 1050-1065
79. Ze Mi#, Qing Yao#, Yan Qi, Jinhai Zheng, Jiahao Liu, Zhenguo Liu, Hongpei Tan, Xiaoqian Ma,Wenhu Zhou*, Pengfei Rong*, Salmonella-Mediated Blood-Brain Barrier Penetration, Tumor Homing and Tumor Microenvironment Regulation for Enhanced Chemo/Bacterial Glioma Therapy,Acta Pharmaceutica Sinica B, 2023, 819-833
80. Shengmei Wang1,4#, Xuanjun Liu1,2#, Minghua Yang3, Linqi Ouyang4, Jinsong Ding2, Shengfeng Wang*1,2,3, andWenhu Zhou*, Non-cytotoxic Nanoparticles Re-educating Macrophages Achieving both Innate and Adaptive Immune Responses for Tumor Therapy,Asian Journal of Pharmaceutical Sciences, 2022, 17 (4) 557-570
81. Yingcai Meng, Jiaojiao Zhu, Jinsong Ding,Wenhu Zhou*, Polyserotonin as a Versatile Coating with pH-responsive Degradation for Anti-tumor Therapy,Chem. Commun., 2022,58, 6713-6716
82. Jiali Deng+, Rui Wang+, Jinsong Ding* andWenhu Zhou*, Macrophages-Regulating Nanomedicines for Sepsis Therapy,Chinese Chemical Letters, 2023,34, 107588
83. Lina Guo+, Shenghui Zhong+, Peng Liu,Man Guo, Jinsong Ding andWenhu Zhou*, Radicals Scavenging MOFs Enabling Targeting Delivery of siRNA for Rheumatoid Arthritis Therapy,Small, 2022, 27, 2202604
84. Hanane Aliouat#, Ying Peng#, Zoya Waseem, Shengfeng Wang, andWenhu Zhou*, Pure DNA scaffolded Drug Delivery Systems for Cancer Therapy,Biomaterials, 2022, 285, 121532
85. Mengzhen Yu#, Yanwen Zhang#, Meirong Fang, Shah Jehan* andWenhu Zhou*, Current Advances of Nanomedicines Delivering Arsenic Trioxide for Enhanced Tumor Therapy,Pharmaceutics, 2022, 14(4), 743
86. Qin Ouyang#, Kai Liu#, Qubo Zhu#, Huiyin Deng, Yuan Le, Wen Ouyang, Xiaoxin Yan,Wenhu Zhou*, Jianbin Tong*, Brain-Penetration and Neuron-Targeting DNA Nanoflowers Co-Delivering miR-124 and Rutin for Synergistic Therapy of Alzheimer's Disease,Small, 2022, 2107534
87. Weidong Sun#, Yiyan Xu#, Ye Yao, Jie Yue, Zhen Wu, Haocheng Li, Guanghui Shen, Yan Liao, Haiyang Wang*, andWenhu Zhou*, Self-oxygenation Mesoporous MnO2 Nanoparticles with Ultra-High Drug Loading Capacity for targeted Arteriosclerosis Therapy,Journal of Nanobiotechnology, 2022, 20, 88
88. Yuan Chen#, Ruiheng Luo#, Jing Li#, Shengfeng Wang, Jinsong Ding, Kai Zhao*, Ben Lu* andWenhu Zhou*,Intrinsic Radical Species Scavenging Activities of Tea Polyphenols Nanoparticles Blocks Pyroptosis in Endotoxin-Induced Sepsis,ACS Nano,2022, 16, 2429-2441
89. Peng Liu+, Ying Peng, Jinsong Ding andWenhu Zhou*, Fenton Metal Nanomedicines for Imaging-guided Combinatorial Chemodynamic Therapy against Cancer,Asian Journal of Pharmaceutical Sciences, 2022, 17, 177-192
90. Yuejia Song, Yaqian Huang, Fang Zhou, Jinsong Ding*,Wenhu Zhou*, Macrophage-targeted nanomedicine for chronic diseases immunotherapy,Chinese Chemical Letters, 2022, 33, 597-612
91. Jiaojiao Zhu, Man Guo, Yanhui Cui, Yingcai Meng, Jinsong Ding, Wenbin Zeng, andWenhu Zhou*, Surface Coating of Pulmonary siRNA Delivery Vectors Enabling Mucus Penetration, Cell Targeting, and Intracellular Radical Scavenging for Enhanced Acute Lung Injury Therapy,ACS Appl. Mater. Interfaces2022, 14, 4, 5090–5100
92. Shah Jehan, Jiaxin Huang, Umar Farooq, Irum Basheer andWenhu Zhou*, Combinatorial effect of thymoquinone with chemo agents for tumor therapy,Phytomedicine, 2022, 98, 153936
93. Pingping Bing,Wenhu Zhou*and Songwen Tan*, Study on the Mechanism of Astragalus Polysaccharide in Treating Pulmonary Fibrosis Based on “Drug-Target-Pathway” Network,Front. Pharmacol.,2022, 13:865065.
94. Peng Liu+, Xinyi Shi+, Ying Peng, Jianming, Hu, Jinsong Ding andWenhu Zhou*, Anti-PD-L1 DNAzyme Loaded Photothermal Mn2+/Fe3+ Hybrid Metal-Phenolic Networks for Cyclically Amplified Tumor Ferroptosis-Immunotherapy,Advanced Healthcare Materials, 2022, 11, 2102315
95. Shengmei Wang, Xuanjun Liu, Shengfeng Wang, Linqi Ouyang, Hui Li, Jinsong Ding, Guiming Deng*, andWenhu Zhou*, Imatinib co-loaded targeted realgar nanocrystal for synergistic therapy of chronic myeloid leukemia,Journal of Controlled Release, 2021, 338, 190-200
96. Yang Zeng, Haiyan Zhou, Jinsong Ding, andWenhu Zhou*, Cell membrane inspired nano-shell enabling long-acting Glucose Oxidase for Melanoma starvation therapy via microneedles-based percutaneous delivery,Theranostics, 2021; 11:8270-8282
97. Peng Liu, Yanbin Zhou, Xinyi Shi, Yu Yuan, Ying Peng, Jinsong Ding, Yong Li*, andWenhu Zhou*,A Cyclic Nano-reactor Achieving Enhanced Photodynamic Tumor Therapy by Reversing Multiple Resistances,J. Nanobiotechnol., 2021, 19, 149
98. Peng Liu, Ying Peng, Yanbin Zhou, Xinyi Shi, Qingnian Li, Jinsong Ding, Yang Gao,* andWenhu Zhou*, Rapamycin as a “One-Stone-Three-Birds” Agent for Cooperatively Enhanced Phototherapies Against Metastatic Breast Cancer,ACS Appl. Mater. Interfaces, 2021, 13, 22, 25674–25684
99. Peng Liu, Xinyi Shi, Shenghui Zhong, Ying Peng, Yan Qi, Jinsong Ding,Wenhu Zhou*, Metal-phenolic networks for cancer theranostics,Biomater. Sci., 2021,9, 2825-2849
100.Shenghui Zhong, Peng Liu, Jinsong Ding* andWenhu Zhou*, Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy,Crystals, 2021, 11(4), 321-334
101.Man Guo, Yingcai Meng, Xiaoqun Qin*, andWenhu Zhou*, Dopamine-Grafted Hyaluronic Acid Coated Hyperbranched Poly(β-Amino Esters)/DNA Nano-Complexes for Enhanced Gene Delivery and Biosafety,Crystals, 2021, 11(4), 347-360
102.Yang Xi, Xin Xie, Ying Peng, Peng Liu, Jinsong Ding* andWenhu Zhou*, DNAzyme-adsorbed polydopamine@MnO2 core–shell nanocomposites for enhanced photothermal therapy via the self-activated suppression of heat shock protein 70,Nanoscale, 2021, 13, 5125-5135
103.Peng Liu, Xin Xie, Miao Liu, Shuo Hu, Jinsong Ding,Wenhu Zhou*,A Smart MnO2 Doped Graphene Oxide Nanosheet for Enhanced Chemo-Photodynamic Combinatorial Therapy via Simultaneous Oxygenation and Glutathione Depletion,Acta Pharmaceutica Sinica B,2021, 11, 823-834
104.Yihua Yang, Lina Guo, Zhe Wang, Peng Liu, Xuanjun Liu, Jinsong Ding,Wenhu Zhou*, Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization,Biomaterials, 2021, 264, 120390
105.Lina Guo, Yang Chen, Ting Wang, Yu Yuan, Yihua Yang, Xiaoli Luo, Shuo Hu, Jinsong Ding* andWenhu Zhou*, Rational design of metal-organic frameworks to deliver methotrexate for targeted rheumatoid arthritis therapy,Journal of Controlled Release, 2021, 330, 119-131
106.Ze Mi#, Lina Guo#, Peng Liu#, Yan Qi, Zhichao Feng, Jiahao Liu, Zhenhu He, Xiao Yang,Shengnan Jiang, Jianzhen Wu, Jinsong Ding,Wenhu Zhou*,and Pengfei Rong*,“Trojan Horse” Salmonella Enabling Tumor Homing of Silver Nanoparticles via Neutrophil Infiltration for Synergistic Tumor Therapy and Enhanced Biosafety,Nano letters, 2021, 21, 1, 414–423
107.Yingcai Meng, Yuan Chen, Jiaojiao Zhu, Yan Qi, Jinsong Ding,Wenhu Zhou*, Polarity Control of DNA Adsorption Enabling Surface Functionalization of CuO Nanozyme for Targeted Tumor Therapy,Materials Horizons,2021, 8, 972-986
108.Mengchang Xu, Fenglin Liu,Wenhu Zhou*, Binsheng He, Songwen Tan*, Preparation and preliminary quality evaluation of aspirin/L-glutamate compound pellets,Journal of Materials Science: Materials in Medicine,2021, 32:116
109.Mengchang Xu,Wenhu Zhou*, Xuncai Chen, Ying Zhou, Binsheng He, Songwen Tan*, Analysis of the biodegradation performance and biofouling in a halophilic MBBR-MBR to improve the treatment of disinfected saline wastewater,Chemosphere, 2021, 269, 128716
110.Hanyong Zhang,Wenhu Zhou*, Xuehui Zhan, Zhenxing Chi, Weiguo Li, Binsheng He, Songwen Tan*, Biodegradation performance and biofouling control of a halophilic biocarriers-MBR in saline pharmaceutical (ampicillin-containing) wastewater treatment,Chemosphere, 2021, 263, 127949
111.Taoli Sun, Wenqun Li, Xiaoliang Tong, Xinyi Liu,Wenhu Zhou*, Xanthohumol attenuates isoprenaline-induced cardiac hypertrophy and fibrosis through regulating PTEN/AKT/mTOR pathway,European Journal of Pharmacology, 2021, 891, 15, 173690
112.Peng Liu, Xuanjun Liu, Yan Cheng, Shenghui Zhong, Xinyi Shi, Shengfeng Wang, Jinsong Ding,Wenhu Zhou*,Core-Shell Nanosystems for Self-Activated Drug-Gene Combinations against Triple-Negative Breast Cancer,ACS Appl. Mater. Interfaces, 2020, 48, 53654-53664
113.Yunbo Nie, Dan Li, Ying Peng, Shengfeng Wang, Jinsong Ding* andWenhu Zhou*,Metal Organic Framework Coated MnO2 Nanosheets Delivering Doxorubicin and Self-activated DNAzyme for Chemo-gene Combinatorial Treatment of Cancer,International Journal of Pharmaceutics, 2020, 585, 1195
114.Ying Peng, Peng Liu, Yingcai Meng, Jinsong Ding* andWenhu Zhou*, Nanoscale Copper(II)-Diethyldithiocarbamate Coordination Polymer as Drug Self-delivery System for Highly Robust and Specific Cancer Therapy,Molecular Pharmaceutics, 2020, 8, 2864-2873
115.Miao Liu, Ying Peng, Yunbo Nie, Peng Liu, Shuo Hu, Jinsong Ding* andWenhu Zhou*,Co-delivery of doxorubicin and DNAzyme using ZnO@polydopamine core-shell nanocomposites for chemo/gene/photothermal therapy,Acta Biomaterialia, 2020, 110, 242-253
116.Peng Liu, Xin Xie, Xinyi Shi, Ying Peng, Jinsong Ding andWenhu Zhou*, Oxygen-Self-Supplying and HIF-1α-Inhibiting Core−Shell Nanosystem for Hypoxia-Resistant Photodynamic Therapy,ACS Appl. Mater. Interfaces2019, 11, 48261−48270
117.Liang Li, Yingcai Meng, Ling Li, Shengfeng Wang, Jinsong Ding* andWenhu Zhou*, A Tetrahedral DNA Nanoflare for Fluorometric Determination of Nucleic Acids and Imaging of MicroRNA Using Toehold Strands,Microchimica Acta, 2019, 186, 824
118.Yang Yihua, Wang Zhe, Peng Ying,Jinsong Ding* andWenhu Zhou*, A Smart pH-Sensitive Delivery System for Enhanced Anticancer Efficacy via Paclitaxel Endosomal Escape,Frontiers in Pharmacology, 2019, DOI: 10.3389/fphar.2019.00010
119.Xiaoli Luo, Xin Xie, Yingcai Meng, Taoli Sun, Jinsong Ding* andWenhu Zhou*, Ligands dissociation induced gold nanoparticles aggregation for colorimetric Al3+ detection,Analytica Chimica Acta, 2019, 1087, 9, 76-85
120.Shengfeng Wang, Jinsong Ding* andWenhu Zhou*, An aptamer-tethered, DNAzyme-embedded molecular beacon for simultaneous detection and regulation of tumor-related genes in living cells,Analyst, 2019, 144, 5098-5107
121.Liu Peng, Guo Binbin, Wang Shengfeng, Jinsong Ding* andWenhu Zhou*, A thermo-responsive and self-healing liposome-in-hydrogel system as an antitubercular drug carrier for localized bone tuberculosis therapy,International Journal of Pharmaceutics, 2019, 558, 101-109
122.Yang Chen, Cejun Yang, Juan Mao, Haigang Li, Ying, Jinsong Ding* andWenhu Zhou*, Spermine Modified Polymeric Micelles with pH-Sensitive Drug Release for Targeted and Enhanced Antitumor Therapy,RSC Advances, 2019, 9, 11026-11037
123.Yingcai Meng, Peng Liu,Wenhu Zhou*, Jinsong Ding*, Juewen Liu, Bioorthogonal DNA Adsorption on Polydopamine Nanoparticles Mediated by Metal Coordination for Highly Robust Sensing in Serum and Living Cells,ACS Nano, 2018, 12, 9070-9080
124.Peng Liu, Shengfeng Wang, Xuanjun Liu, Jinsong Ding* andWenhu Zhou*, Platinated graphene oxide: A nanoplatform for efficient gene-chemo combination cancer therapy,European journal of pharmaceutical sciences, 2018, 121, 319-329
125.Binbin Guo, Yuqiao Zhang, Shengfeng Wang, Jinsong Ding andWenhu Zhou*, The pharmacokinetics of morphine and codeine in human plasma and urine after oral administration of Qiangli Pipa Syrup,Journal of forensic science, 2018, 63, 1221-1228
126.Shengfeng Wang, Chuantong Zhao, Peng Liu, Zhe Wang, Jinsong Ding* andWenhu Zhou*, Facile construction of dual-targeting delivery system by using lipid capped polymer nanoparticles for anti-glioma therapy.RSC Advances, 2018, 8, 444–453
127.Wenhu Zhou* and Juewen Liu*, "Multi-metal-dependent nucleic acid enzymes",Metallomics,2018, 10, 30-48
128.Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Splitting a DNAzyme enabling Na+-dependent FRET signal from the embedded aptamer",Organic & Biomolecular Chemistry, 2017, 15, 6959-6966
129.Wenhu Zhou, Runjhun Saran, Jinsong Ding and Juewen Liu*, "Two Completely Different Mechanisms for Highly Specific Na+ Recognition by DNAzymes",ChemBioChem, 2017, 18, 1828-1835
130.Wenhu Zhou, Runjhun Saran and Juewen Liu*, "Metal Sensing by DNA",Chemical Reviews, 2017, 117, 8272–8325
131.Wenhu Zhou, Runjhun Saran, Po-Jung Jimmy Huang, Jinsong Ding and Juewen Liu*, "An Exceptionally Selective DNA Cooperatively Binding Two Ca2+ Ions",ChemBioChem, 2017, 18, 518-522.
132.Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Theranostic DNAzymes",Theranostics, 2017, 7, 1010-1025
133.Wenhu Zhou, Jinsong Ding and Juewen Liu*, "2-Aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver",Biosensors & Bioelectronics, 2017, 87, 171-177
134.Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A highly specific sodium aptamer probed by 2-aminopurine for robust Na+ sensing",Nucleic Acids Research, 2016, 44, 10377-10385
135.Wenhu Zhou, Tianmeng Yu, Mahsa Vazin, Jinsong Ding and Juewen Liu*, "Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis",Inorganic Chemistry, 2016, 55, 8193–8200
136.Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence",ChemBioChem, 2016, 17, 1563–1570
137.Wenhu Zhou, Mahsa Vazin, Tianmeng Yu Jinsong Ding and Juewen Liu*, "In Vitro Selection of Chromium-Dependent DNAzymes for Sensing Cr(III) and Cr(VI)",Chemistry, a European Journal, 2016, 22, 9835-9840
138.Wenhu Zhou, Yupei Zhang, Jinsong Ding* and Juewen Liu*, "In Vitro Selection in Serum: RNA-Cleaving DNAzymes for Measuring Ca2+ and Mg2+",ACS Sensors, 2016, 1, 600-606
139.Wenhu Zhou, Jinsong Ding and Juewen Liu*, "An Efficient Lanthanide-Dependent DNAzyme Cleaving 2’-5’ Linked RNA",ChemBioChem, 2016, 17, 890-894
140.Wenhu Zhou, Runjhun Saran, Qingyun Chen, Jinsong Ding and Juewen Liu*, "A New Na+-Dependent RNA-Cleaving DNAzyme with over 1000-fold Rate Acceleration by Ethanol",ChemBioChem, 2016, 17, 159-163
141.Wenhu Zhou, Yupei Zhang, Po-Jung Jimmy Huang, Jinsong Ding, and Juewen Liu*, "A DNAzyme requiring two different metal ions at two distinct sites",Nucleic Acids Research, 2016, 44, 354-363
142.Wenhu Zhou, Jinsong Ding* and Juewen Liu*, "A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold",Chemical Communications, 2015, 51, 12084-12087
143.Wenhu Zhou, Qingyun Chen, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "DNAzyme Hybridization, Cleavage, Degradation and Sensing in Undiluted Human Blood Serum",Analytical Chemistry, 2015, 87, 4001–4007
144.Wenhu Zhou, Feng Wang, Jinsong Ding* and Juewen Liu*, "Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles",ACS Applied Materials & Interfaces, 2014, 6, 14795-14800
145.Wenhu Zhou, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "Aptamer-based biosensors for biomedical diagnostics",Analyst, 2014, 139, 2627-2640
146.Wenhu Zhou, Yanbin Zhou, Jianping Wu, Zhenbao Liu, Huanzhe Zhao, Juewen Liu*, and Jinsong Ding*. "Aptamer-nanoparticle bioconjugates enhance Intracellular delivery of vinorelbine to breast cancer cells",Journal of Drug Targeting, 2014, 22(1): 57-66
147.Wenhu Zhou, Shiying He, Yijun Yang, Dan Jian, Xiang Chen*, and Jinsong Ding*," Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma”,Drug development and industrial pharmacy, 2015, 41 (7), 1109-1119
