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教师风采
周文虎教授

 

周文虎

中共党员

博士,博士生导师,院团委副书记

中南大学,湘雅药学院,特聘教授

电话:15111469284

邮箱:zhouwenhuyaoji@163.com;

zhouwenhu@csu.edu.cn

 

教育经历:

2013.09-2016.12

中南大学,药学院,药剂学系,博士

导师:丁劲松

2014.10-2016.09

University of Waterloo;国家公派联合培养博士

导师:Juewen Liu

2014.02-2014.09

University of Waterloo;访问博士

导师:Juewen Liu

2010.09-2013.06

中南大学,药学院,药剂学系,硕士

导师:丁劲松

2006.09-2010.06

中南大学,药学院,学士

 

工作经历:

2017.03-至今    中南大学    特聘教授

研究领域:

 应用基础研究:

1. 多功能纳米载体的构建与生物医学应用;

2. 基于疾病病理机制的纳米药物设计;

3. 功能核酸(如核酸适配体、DNA酶)在疾病诊疗中的应用;

4. 新型微生物制剂(如细菌等)的开发

 应用研究:药物制剂开发与临床评价

科研成果:

 科研项目:

国家自然科学基金,可突破免疫屏障的“隐形”沙门氏菌联合放疗免疫增敏用于宫颈癌的治疗研究,57万,主持

国家自然科学基金,基于功能核酸串联的诊疗一体化探针的构建与应用研究,25万,主持

中央高校基本科研业务费专项基金,“一体三用”的DNAzyme递送策略研究,65万,主持

中央高校基本科研业务费专项基金,特聘教授,120万,主持

硫酸羟氯喹片生物等效性预试验合作研究,横向研究,71万,主持

SM-1细胞活性与细胞内Procaspase-3酶原含量的相关性研究,横向研究,4.4万,主持

 发表论文:以第一/通讯作者身份在国际著名学术期刊Chemical Reviews, ACS Nano, Nucleic Acids Research, Theranostics, ACS Applied Materials & Interfaces等累计发表SCI学术论文33(一区21篇,二区10篇),其中单篇最高IF=52.613IF>10分论文4篇;6篇论文被ESI收录为高被引论文,1篇热点论文。

代表性论文 (截止2019)

1.         Miao Liu, Ying Peng, Yunbo Nie, Peng Liu, Shuo Hu, Jinsong Ding* and Wenhu Zhou*, Co-delivery of doxorubicin and DNAzyme using ZnO@polydopamine core-shell nanocomposites for chemo/gene/photothermal therapy, Acta Biomaterialia, doi.org/10.1016/j.actbio.2020.04.041

2.         Peng Liu, Xin Xie, Xinyi Shi, Ying Peng, Jinsong Ding and Wenhu Zhou*, Oxygen-Self-Supplying and HIF-1α-Inhibiting Core−Shell Nanosystem for Hypoxia-Resistant Photodynamic Therapy, ACS Appl. Mater. Interfaces 2019, 11, 48261−48270

3.         Liang Li, Yingcai Meng, Ling Li, Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, A Tetrahedral DNA Nanoflare for Fluorometric Determination of Nucleic Acids and Imaging of MicroRNA Using Toehold Strands, Microchimica Acta, 2019, 186, 824

4.         Yang Yihua, Wang Zhe, Peng Ying, Jinsong Ding* and Wenhu Zhou*, A Smart pH-Sensitive Delivery System for Enhanced Anticancer Efficacy via Paclitaxel Endosomal Escape, Frontiers in Pharmacology, 2019, DOI: 10.3389/fphar.2019.00010

5.         Xiaoli Luo, Xin Xie, Yingcai Meng, Taoli Sun, Jinsong Ding* and Wenhu Zhou*, Ligands dissociation induced gold nanoparticles aggregation for colorimetric Al3+ detection, Analytica Chimica Acta, 2019, 1087, 9, 76-85

6.         Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, An aptamer-tethered, DNAzyme-embedded molecular beacon for simultaneous detection and regulation of tumor-related genes in living cells, Analyst, 2019, 144, 5098-5107

7.         Liu Peng, Guo Binbin, Wang Shengfeng, Jinsong Ding* and Wenhu Zhou*, A thermo-responsive and self-healing liposome-in-hydrogel system as an antitubercular drug carrier for localized bone tuberculosis therapy, International Journal of Pharmaceutics, 2019, 558, 101-109

8.         Yang Chen, Cejun Yang, Juan Mao, Haigang Li, Ying, Jinsong Ding* and Wenhu Zhou*, Spermine Modified Polymeric Micelles with pH-Sensitive Drug Release for Targeted and Enhanced Antitumor Therapy, RSC Advances, 2019, 9, 11026-11037

9.         Yingcai Meng, Peng Liu, Wenhu Zhou*, Jinsong Ding*, Juewen Liu, Bioorthogonal DNA Adsorption on Polydopamine Nanoparticles Mediated by Metal Coordination for Highly Robust Sensing in Serum and Living Cells, ACS Nano, 2018, 12, 9070-9080

10.     Peng Liu, Shengfeng Wang, Xuanjun Liu, Jinsong Ding* and Wenhu Zhou*, Platinated graphene oxide: A nanoplatform for efficient gene-chemo combination cancer therapy, European journal of pharmaceutical sciences, 2018, 121, 319-329

11.     Binbin Guo, Yuqiao Zhang, Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, The pharmacokinetics of morphine and codeine in human plasma and urine after oral administration of Qiangli Pipa Syrup, Journal of forensic science, 2018, 63, 1221-1228

12.     Shengfeng Wang, Chuantong Zhao, Peng Liu, Zhe Wang, Jinsong Ding* and Wenhu Zhou*, Facile construction of dual-targeting delivery system by using lipid capped polymer nanoparticles for anti-glioma therapy. RSC Advances, 2018, 8, 444–453

13.     Wenhu Zhou* and Juewen Liu*, "Multi-metal-dependent nucleic acid enzymes", Metallomics, 2018, 10, 30-48

14.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Splitting a DNAzyme enabling Na+-dependent FRET signal from the embedded aptamer", Organic & Biomolecular Chemistry, 2017, 15, 6959-6966

15.     Wenhu Zhou, Runjhun Saran, Jinsong Ding and Juewen Liu*, "Two Completely Different Mechanisms for Highly Specific Na+ Recognition by DNAzymes", ChemBioChem, 2017, 18, 1828-1835

16.     Wenhu Zhou, Runjhun Saran and Juewen Liu*, "Metal Sensing by DNA", Chemical Reviews, 2017, 117, 8272–8325

17.     Wenhu Zhou, Runjhun Saran, Po-Jung Jimmy Huang, Jinsong Ding and Juewen Liu*, "An Exceptionally Selective DNA Cooperatively Binding Two Ca2+ Ions", ChemBioChem, 2017, 18, 518-522.

18.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Theranostic DNAzymes", Theranostics, 2017, 7, 1010-1025

19.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "2-Aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver", Biosensors & Bioelectronics, 2017, 87, 171-177

20.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A highly specific sodium aptamer probed by 2-aminopurine for robust Na+ sensing", Nucleic Acids Research, 2016, 44, 10377-10385

21.     Wenhu Zhou, Tianmeng Yu, Mahsa Vazin, Jinsong Ding and Juewen Liu*, "Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis", Inorganic Chemistry, 2016, 55, 8193–8200

22.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence", ChemBioChem, 2016, 17, 1563–1570

23.     Wenhu Zhou, Mahsa Vazin, Tianmeng Yu Jinsong Ding and Juewen Liu*, "In Vitro Selection of Chromium-Dependent DNAzymes for Sensing Cr(III) and Cr(VI)", Chemistry, a European Journal, 2016, 22, 9835-9840

24.     Wenhu Zhou, Yupei Zhang, Jinsong Ding* and Juewen Liu*, "In Vitro Selection in Serum: RNA-Cleaving DNAzymes for Measuring Ca2+ and Mg2+", ACS Sensors, 2016, 1, 600-606

25.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "An Efficient Lanthanide-Dependent DNAzyme Cleaving 2’-5’ Linked RNA", ChemBioChem, 2016, 17, 890-894

26.     Wenhu Zhou, Runjhun Saran, Qingyun Chen, Jinsong Ding and Juewen Liu*, "A New Na+-Dependent RNA-Cleaving DNAzyme with over 1000-fold Rate Acceleration by Ethanol", ChemBioChem, 2016, 17, 159-163

27.     Wenhu Zhou, Yupei Zhang, Po-Jung Jimmy Huang, Jinsong Ding, and Juewen Liu*, "A DNAzyme requiring two different metal ions at two distinct sites", Nucleic Acids Research, 2016, 44, 354-363

28.     Wenhu Zhou, Jinsong Ding* and Juewen Liu*, "A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold", Chemical Communications, 2015, 51, 12084-12087

29.     Wenhu Zhou, Qingyun Chen, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "DNAzyme Hybridization, Cleavage, Degradation and Sensing in Undiluted Human Blood Serum", Analytical Chemistry, 2015, 87, 4001–4007

30.     Wenhu Zhou, Feng Wang, Jinsong Ding* and Juewen Liu*, "Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles", ACS Applied Materials & Interfaces, 2014, 6, 14795-14800

31.     Wenhu Zhou, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "Aptamer-based biosensors for biomedical diagnostics", Analyst, 2014, 139, 2627-2640

32.     Wenhu Zhou, Yanbin Zhou, Jianping Wu, Zhenbao Liu, Huanzhe Zhao, Juewen Liu*, and Jinsong Ding*. "Aptamer-nanoparticle bioconjugates enhance Intracellular delivery of vinorelbine to breast cancer cells", Journal of Drug Targeting, 2014, 22(1): 57-66

33.     Wenhu Zhou, Shiying He, Yijun Yang, Dan Jian, Xiang Chen*, and Jinsong Ding*," Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma”, Drug development and industrial pharmacy, 2015, 41 (7), 1109-1119

   友情链接

中南大学湘雅药学院  地址:长沙市桐梓坡路172号
邮编:410013