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导师简介
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邹振兴副研究员
2020-01-13 16:28  

证件照

邹振兴,男,1987年生,副研究员,硕士生导师,博士/博士后。中南大学湘雅药学院药学实验中心副主任,湖南省药学会中药与天然药物委员会青年委员会副主任委员。2009年本科毕业于浙江海洋学院食品与药学学院医学院,2012.62016.6年先后获中南大学湘雅药学院医学硕士和医学博士学位,2016.11-2018.12在中南大学湘雅医院从事博士后研究,2019.1入职中南大学湘雅药学院。

近年来一直从事天然药物化学教学、科研及中药新药研发等相关工作。主要致力于药用蕨类植物(卷柏科、石松科)及内生菌化学成分多样性及生物学功能研究,初步探明了其传统功效与物质基础内在联系,以及生物学功能差异的规律,发现了多个具有显著抗肿瘤、抗炎、神经保护等活性的天然活性先导物。先后在PhytochemistryFitoterapiaChinese Chemical LettersFrontiers in Pharmacology等国际期刊发表30余篇SCI论文,现为FitoterapiaNPRCCL等国际期刊审稿人;先后获得国自青年基金,省自青年基金和中国博士后基金等资助,参与其他国家、省部级及新药研发课题15余项,申请国家发明专利1项。

研究方向:

1.       传统中药、药用植物及其内生真菌天然活性小分子化合物的发现、结构修饰以及生物学功能评价(肿瘤、神经保护、抗炎、抗菌等)

2.       中药新药及健康产品研发

课题组介绍:

http://yxy.csu.edu.cn/info/1097/3767.htm

近年主持或参与课题:

1.       国家自然科学基金面上项目,基于herquline A等天然产物生物合成的酚去芳构化生物催化体系的研究和应用,2019/01-2022/12,在研,参加

2.       国家自然科学青年基金,两种卷柏新颖黄酮类成分及BACE1抑制活性研究,2018/01-2020/12,在研,主持

3.       湖南省自然科学青年基金,石上柏新型天然BACE1抑制剂的发现与研究,2018/01-2020/12,在研,主持

4.       中国博士后基金面上项目,基于多靶点作用特征的中药石上柏抗AD药效物质基础研究,2018/01-2018/12,已结题,主持

5.       国家自然科学青年基金,DMATS家族酶催化黄酮定向异戊烯基化的方法研究及其合成应用,2018/01-2020/12,在研,参加

6.       中南大学博士后科研启动项目,基于深绿卷柏新颖黄酮类成分的抗AD新药临床前研究,2016/11-2018/11,已结题,主持

7.       湖南省自然科学基金面上项目,基于COX-2靶点的黑顶卷柏抗肿瘤作用研究,2016/01-2018/12,已结题,参加

8.       海口市应用技术研究与开发经费专项重点项目,海南石上柏新型抗肿瘤活性成分及其作用机制研究,2015/01-2017/12,已结题,参加

9.       国家自然科学基金面上项目,卷柏属植物COX-2抑制剂先导物的发现及抗肺癌作用机制研究,2014/01-2017/12,已结题,参加

代表性文章:

1.       Zhenxing Zou, Guishan Tan, Qi Huang, Huihui Sun, Luqiong Huo, Wanqi Zhong, Liyun Zhao, Hongxin Liu*, Haibo Tan*. Brachyanins A-C, pinene-derived meroterpenoids and phloroglucinol derivative from Leptospermum brachyandrum, Fitoterapia, 2018, (130): 184˗189.

2.       Zhenxing Zou, Pingsheng Xu, Guogang Zhang, Fei Cheng, Kai Chen, Jing Li, Weixing Zhu, Dongsheng Cao, Kangping Xu*, Guishan Tan*, Selagintriflavonoids with BACE1 inhibitory activity from the fern Selaginella doederleinii, Phytochemistry, 2017, (134): 114˗121.

3.       Zhenxing Zou, Kangping Xu, Pingsheng Xu, Xiaomin Li, Fei Cheng, Jing Li, Xia Yu, Dongsheng Cao, Li Dan, Wei Zeng, Guogang Zhang*, Guishan Tan*, Seladoeflavones A-F, six novel flavonoids from Selaginella doederleinii, Fitoterapia, 2017, (116): 66˗71.

4.       Zhenxing Zou, Guishan Tan, Guogang Zhang, Xia Yu, Pingsheng Xu*, Kangping Xu*, New cytotoxic apigenin derivatives from Selaginella doederleinii, Chinese Chemical Letters, 2017, 28(5): 931˗934.

5.       Zhenxing Zou, Pingsheng Xu, Canrong Wu, Weixing Zhu, Gangzhi Zhu, Xiaoai He, Guogang Zhang, Jianzhong Hu, Shao Liu, Wei Zeng, Kangping Xu*, Guishan Tan*, Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron, Fitoterapia, 2016, (111): 124˗129.

6.       Zhenxing Zou, Kangping Xu, Fushuang Li, Hui Zou, Minzhen Liu, Qiong Zhang, Kai Yu, Lanfang Zhao, Leihong Tan, Guishan Tan*, A new pyrrole alkaloid from Selaginella moellendorfii Hieron, Chinese Chemical Letters, 2013, 24(2): 114˗116.

7.       Lifei Liu, Huihui Sun, Jianbing Tan, Qi Huang, Fei Cheng, Kangping Xu, Zhenxing Zou*, Guishan Tan*, New cytotoxic biflavones from Selaginella doederleinii, Natural Product Research, 2019, online, DOI: 10.1080/14786419.2019.1611813.

8.       Fei Cheng, Kangping Xu, Lifei Liu, Caiping Yao, Pingsheng Xu, Gan Zhou, Dai Li, Xiaomin Li, Kai Chen, Zhenxing Zou*, Guishan Tan*, New neolignans from Selaginella picta and their protective effect on HT-22 cells, Fitoterapia, 2018, (127): 69˗73.

9.       Wei Zeng, Caiping Yao, Pingsheng Xu, Guogang Zhang, Zhaoqian Liu, Kangping Xu, Zhenxing Zou*, Guishan Tan*, A new neolignan from Selaginella moellendorffii Hieron, Natural Product Research, 2017, 19(31): 2223˗2227.

10.    Qi Huang, Jianbing Tan, Xiangchang Zeng, Yaqin Wang, Zhenxing Zou*, Dongsheng Ouyang*, Lignans and phenolic constituents from Eucommia ulmoides Oliver, Natural Product Research, 2019, ASAP, online, DOI: 10.1080/14786419.2019.1700250.

11.    Qiuzhu Dong, Zhenxing Zou, Xiaohui Jia, Xia Yu, Jing Li, Wenhao Zhou, Huihui Sun, Wei Wu, Guishan Tan, Kangping Xu*, Cytotoxic polyhydroxy serratene triterpenoids from Lycopodium complanatum, Bioorganic Chemistry, 2019, (87): 373˗379.

12.    Kangping Xu, Can Yang, Yuanyuan Xu, Dan Li, Shumin Bao, Zhenxing Zou, Fenghua Kang, Guishan Tan, Shu-Ming Li, Xia Yu*, Selective geranylation of biflavonoids by Aspergillus terreus aromatic prenyltransferase (AtaPT), Organic & Biomolecular Chemistry, 2019, ASAP, online, DOI: 10.1039/C9OB02296A.

13.    Xi Chen, Pingsheng Xu, Zhenxing Zou, Yang Liu, Wenhao Zhou, Qin Ren, Dan Li, Xiaomin Li, Kangping Xu, Guishan Tan*, Sinensiols B-G, six novel neolignans from selaginella sinensis, Fitoterapia, 2019, (134): 256˗263.

14.    Fei Cheng, Zhenxing Zou, Pingsheng Xu, Shuihan Zhang, Yan Zhang, Caiping Yao, Kangping Xu, Guishan Tan*, Pictalignans D-F, three new neolignan derivatives from Selaginella picta, Natural Product Research, 2019, ASAP, online, DOI: 10.1080/14786419.2018.1560284.

15.    Yang Liu, Jing Li, Dan Li, Xiaomin Li, Dai Li, Gan Zhou, Kangping Xu, Fenghua Kang, Zhenxing Zou, Pingsheng Xu*, Guishan Tan*, Anti-cholinesterase activities of constituents isolated from Lycopodiastrum casuarinoides, Fitoterapia, 2019, (139): 104366.

16.    Yinhua Deng, Ningning Wang, Zhenxing Zou, Lin Zhang, Kangping Xu, Alex F. Chen, Dongsheng Cao*, Guishan Tan*, Multi-target Screening and Experimental Validation of Natural Products from Selaginella Plants against Alzheimer’s Disease, Frontiers in Pharmacology, 2017, (8): 539.

17.    Rui Liu, Hui Zou, Zhenxing Zou, Fei Cheng, Xia Yu, Pingsheng Xu, Xiaomin Li, Dai Li, Kangping Xu*, Guishan Tan*, Two new anthraquinone derivatives and one new triarylbenzophenone analog from Selaginella tamariscina, Natural Product Research, 2018, ASAP, online, DOI: 10.1080/14786419.2018.1452008.

18.    Caiping Yao, Zhenxing Zou, Yan Zhang, Jing Li, Fei Cheng, Pingsheng Xu, Gan Zhou, Xiaomin Li, Kangping Xu*, Guishan Tan*, New adenine analogues and a pyrrole alkaloid from Selaginella delicatula, Natural Product Research, 2019, 14(33): 1985˗1991.

19.    Rui Liu, Hui Zou, Pingsheng Xu, Zhenxing Zou, Jing Li, Fei Cheng, Ruihuan Liu, Gan Zhou, Kangping Xu*, Guishan Tan*, Uncinatic acids A-C, three new carboxylated flavonoids from Selaginella uncinata, Chinese Chemical Letters, 2017, 28(7): 1465˗1468.

20.    Jing Li, Pingsheng Xu, Zhenxing Zou, Hui Zou, Hongping Long, Leihong Tan, Ruihuan Liu, Yikun Wang, Kangping Xu*, Guishan Tan*. Three new compounds from the roots of Juglans mandshurica Maxim. Phytochemistry Letters, 2017, (20): 40˗44.

联系方式:

通讯地址:湖南省长沙市桐梓坡路172号中南大学湘雅药学院(孝骞楼614),邮编:410013

Tel0731-82650395

E-mailzouzhenxing@csu.edu.cn

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中南大学湘雅药学院  地址:长沙市桐梓坡路172号
邮编:410013