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教师风采
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于霞 副教授
2017-07-06 17:18  

于霞,副教授,硕士生导师

新颖天然产物发现/结构修饰、生物合成及开发应用课题组成员

(课题组简介链接:http://yxy.csu.edu.cn/info/1097/3767.htm)

电子邮箱: xyu226@csu.edu.cn

教育和工作经历

2003/9–2007/7,北京大学,药学院,学士

2007/9–2009/7,北京大学,药学院,硕士

2009/10–2013/9,马尔堡大学,药学院,博士

2013/12-2014/12,肯塔基大学,药学院,博士后

2015/1-2016/6,加州大学洛杉矶分校,化学与生物分子工程学院,博士后

研究领域和研究方向

1,微生物来源重要次生代谢产物的生物合成研究

2,新颖生物合成酶催化机理研究

3,基于药物靶标的次生代谢产物的基因组挖掘

4,高效生物酶合成法和生物转化法的构建。

代表性论文

[1] X. Yu, F. Liu, Y. Zou, M. Tang, L. Hang, K. N. Houk, and Y. Tang. Biosynthesis of Strained Piperazine Alkaloids: Uncovering the Concise Pathway of Herquline A, Journal of the American Chemical Society, 2016, 138, 13529–13532. (影响因子:13.038)

[2] X. Yu,G. Zocher, X. Xie, M. Liebhold, S. Schütz, T. Stehle, and S.-M. Li. Catalytic mechanism of stereospecific formation ofcis-configured prenylated pyrroloindoline diketopiperazines by indole prenyltransferases, Chemistry & Biology, 2013, 20, 1492-1501.

[3] S. Yin#,X. Yu#(并列一作), Q. Wang, X. Liu, and S.-M. Li. Identification of a brevianamide F reverse prenyltransferase BrePT fromAspergillus versicolorwith a broad substrate specificity towards tryptophan-containing cyclic dipeptides, Applied Microbiology and Biotechnology, 2013, 97, 1649-1660.

[4] X. Yu, Y. Liu, X. Xie, X. Zheng, and S.-M. Li. Biochemical characterization of indole prenyltransferases: filling the last gap of prenylation positions by a 5-dimethylallyltryptophansynthase fromAspergillus clavatus, Journal of Biological Chemistry, 2012, 287, 1371-1380.

[5] X. Yu, A. Yang, W. Lin, and S.-M. Li. Friedel–Crafts alkylation on indolocarbazoles catalyzed by two dimethylallyltryptophan synthases fromAspergillus, Tetrahedron Letters, 2012, 53, 6861-6864.

[6] X. Yuand S.-M. Li, Prenyltransferases of the dimethylallyltryptophan synthase superfamily, Methods in Enzymology, 2012, 516, 259-278.

[7] X. Yu, and S.-M. Li. Prenylation of flavonoids by using a dimethylallyltryptophan synthase 7-DMATS fromAspergillus fumigatus, Chembiochem, 2011, 12, 2280-2283.

[8] X. Yu, X. Xie, and S.-M. Li. Substrate promiscuity of secondary metabolite enzymes: prenylation of hydroxynaphthalenes by fungal indole prenyltransferases, Applied Microbiology and Biotechnology, 2011, 92, 737-748.

[9] W. Yin#,X. Yu#(并列一作), X. Xie, and S.-M. Li. Preparation of pyrrolo[2,3-b]indoles carrying a ß-configured reverse C3-dimethylallyl moiety by using a recombinant prenyltransferase CdpC3PT, Organic & Biomolecular Chemistry, 2010, 8, 2430-2438.

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