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博士生导师
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周文虎教授
2017-11-22 11:41   审核人:

周文虎

中共党员

医学博士,博士生导师

中南大学湘雅药学院,药剂学系,特聘教授

邮箱:zhouwenhuyaoji@163.com, zhouwenhu@csu.edu.cn

 

教育经历:

2014.10-2016.09

University of Waterloo;国家公派联合培养博士

2014.02-2014.09

University of Waterloo;访问博士

2013.09-2016.12

中南大学,药学院,药剂学系,医学博士

2010.09-2013.06

中南大学,药学院,药剂学系,医学硕士

2006.09-2010.06

中南大学,药学院,理学学士

 

工作经历:

2017.03-    中南大学, 特聘教授

研究领域:

纳米递药系统;经皮给药系统;功能核酸的筛选、表征、与纳米材料键合、及在药剂学与医学诊断治疗中的应用基础研究。

科研成果:

 科研项目:

新型金属离子分子信标筛选及在药物制剂质量控制中的应用研究,中南大学科学研究启动基金,特聘教授,120万,主持

国家自然科学基金,编号:81573774,药物相互作用对共包载盐霉素和siRNA纳米给药系统抗肿瘤效应的影响及其分子机制研究,参与。

 发表论文:

Chemical Reviews, Theranostics, ACS Applied Materials & Interfaces, Biosensors & Bioelectronics, Chemical Communications等杂志发表第一作者或通讯作者SCI论文22篇,单篇最高影响因子为47.928,其中4篇论文被ESI收录为高被引论文。

代表性论文有:

1.         Binbin Guo, Yuqiao Zhang, Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*The pharmacokinetics of morphine and codeine in human plasma and urine after oral administration of Qiangli Pipa Syrup, Journal of forensic science, in press, 2017

2.         Wenhu Zhou* and Juewen Liu*, "Multi-metal-dependent nucleic acid enzymes", Metallomics, in press, 2017

3.         Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Splitting a DNAzyme enabling Na+-dependent FRET signal from the embedded aptamer", Organic & Biomolecular Chemistry, 2017, 15, 6959-6966

4.         Wenhu Zhou, Runjhun Saran, Jinsong Ding and Juewen Liu*, "Two Completely Different Mechanisms for Highly Specific Na+ Recognition by DNAzymes", ChemBioChem, 2017, 18, 1828-1835

5.         Wenhu Zhou, Runjhun Saran and Juewen Liu*, "Metal Sensing by DNA", Chemical Reviews, 2017, 117, 8272–8325

6.         Wenhu Zhou, Runjhun Saran, Po-Jung Jimmy Huang, Jinsong Ding and Juewen Liu*, "An Exceptionally Selective DNA Cooperatively Binding Two Ca2+ Ions", ChemBioChem, 2017, 18, 518-522.

7.         Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Theranostic DNAzymes", Theranostics, 2017, 7, 1010-1025

8.         Wenhu Zhou, Jinsong Ding and Juewen Liu*, "2-Aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver", Biosensors & Bioelectronics, 2017, 87, 171-177

9.         Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A highly specific sodium aptamer probed by 2-aminopurine for robust Na+ sensing", Nucleic Acids Research, 2016, 44, 10377-10385

10.     Wenhu Zhou, Tianmeng Yu, Mahsa Vazin, Jinsong Ding and Juewen Liu*, "Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis", Inorganic Chemistry, 2016, 55, 8193–8200

11.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence", ChemBioChem, 2016, 17, 1563–1570

12.     Wenhu Zhou, Mahsa Vazin, Tianmeng Yu Jinsong Ding and Juewen Liu*, "In Vitro Selection of Chromium-Dependent DNAzymes for Sensing Cr(III) and Cr(VI)", Chemistry, a European Journal, 2016, 22, 9835-9840

13.     Wenhu Zhou, Yupei Zhang, Jinsong Ding* and Juewen Liu*, "In Vitro Selection in Serum: RNA-Cleaving DNAzymes for Measuring Ca2+ and Mg2+", ACS Sensors, 2016, 1, 600-606

14.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "An Efficient Lanthanide-Dependent DNAzyme Cleaving 2´-5´ Linked RNA", ChemBioChem, 2016, 17, 890-894

15.     Wenhu Zhou, Runjhun Saran, Qingyun Chen, Jinsong Ding and Juewen Liu*, "A New Na+-Dependent RNA-Cleaving DNAzyme with over 1000-fold Rate Acceleration by Ethanol", ChemBioChem, 2016, 17, 159-163

16.     Wenhu Zhou, Yupei Zhang, Po-Jung Jimmy Huang, Jinsong Ding, and Juewen Liu*, "A DNAzyme requiring two different metal ions at two distinct sites", Nucleic Acids Research, 2016, 44, 354-363

17.     Wenhu Zhou, Jinsong Ding* and Juewen Liu*, "A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold", Chemical Communications, 2015, 51, 12084-12087

18.     Wenhu Zhou, Qingyun Chen, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "DNAzyme Hybridization, Cleavage, Degradation and Sensing in Undiluted Human Blood Serum", Analytical Chemistry, 2015, 87, 4001–4007

19.     Wenhu Zhou, Feng Wang, Jinsong Ding* and Juewen Liu*, "Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles", ACS Applied Materials & Interfaces, 2014, 6, 14795-14800

20.     Wenhu Zhou, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "Aptamer-based biosensors for biomedical diagnostics", Analyst, 2014, 139, 2627-2640

21.     Wenhu Zhou, Yanbin Zhou, Jianping Wu, Zhenbao Liu, Huanzhe Zhao, Juewen Liu*, and Jinsong Ding*. "Aptamer-nanoparticle bioconjugates enhance Intracellular delivery of vinorelbine to breast cancer cells", Journal of Drug Targeting, 2014, 22(1): 57-66

22.     Wenhu Zhou, Shiying He, Yijun Yang, Dan Jian, Xiang Chen*, and Jinsong Ding*," Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma”, Drug development and industrial pharmacy, 2015, 41 (7), 1109-1119

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