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博士生导师
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周文虎教授
2018-08-24 09:20   审核人:

 

 

 

周文虎

中共党员

博士,博士生导师

中南大学湘雅药学院,药剂学系,特聘教授

电话:15111469284

邮箱:zhouwenhuyaoji@163.com

 

教育经历:

2014.10-2016.09

University of Waterloo;国家公派联合培养博士

2014.02-2014.09

University of Waterloo;访问博士

2013.09-2016.12

中南大学,药学院,药剂学系,博士

2010.09-2013.06

中南大学,药学院,药剂学系,硕士

2006.09-2010.06

中南大学,药学院,学士

 

工作经历:

2017.03-    中南大学, 特聘教授

研究领域:

 应用基础研究:纳米药物递送;基于功能核酸的纳米诊疗研究;纳米材料表界面

 应用研究:缓控释制剂、药物经皮肤传递系统的研究

科研成果:

 科研项目:

国家自然科学基金,基于功能核酸串联的诊疗一体化探针的构建与应用研究,25万,主持;

中南大学创新驱动计划,“一体三用”的DNAzyme递送策略研究,65万,主持;

中南大学科学研究启动基金,特聘教授,120万,主持

 发表论文:以第一/通讯作者身份在国际著名学术期刊Chemical Reviews, ACS Nano, Nucleic Acids Research, Theranostics, ACS Applied Materials & Interfaces等累计发表SCI学术论文25篇,其中6篇论文被ESI收录为高被引论文。

代表性论文有:

1.         Yingcai Meng, Peng Liu, Wenhu Zhou*, Jinsong Ding*, Juewen Liu, Bioorthogonal DNA Adsorption on Polydopamine Nanoparticles Mediated by Metal Coordination for Highly Robust Sensing in Serum and Living Cells, ACS Nano, 2018, DOI:10.1021/acsnano.8b03019

2.         Peng Liu, Shengfeng Wang, Xuanjun Liu, Jinsong Ding* and Wenhu Zhou*, Platinated graphene oxide: A nanoplatform for efficient gene-chemo combination cancer therapy, European journal of pharmaceutical sciences, 2018, 121, 319-329

3.         Binbin Guo, Yuqiao Zhang, Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, The pharmacokinetics of morphine and codeine in human plasma and urine after oral administration of Qiangli Pipa Syrup, Journal of forensic science, 2018, 63, 1221-1228

4.         Wenhu Zhou* and Juewen Liu*, "Multi-metal-dependent nucleic acid enzymes", Metallomics, 2018, 10, 30-48

5.         Shengfeng Wang, Chuantong Zhao, Peng Liu, Zhe Wang, Jinsong Ding* and Wenhu Zhou*, Facile construction of dual-targeting delivery system by using lipid capped polymer nanoparticles for anti-glioma therapy. RSC Advances, 2018, 8, 444–453

6.         Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Splitting a DNAzyme enabling Na+-dependent FRET signal from the embedded aptamer", Organic & Biomolecular Chemistry, 2017, 15, 6959-6966

7.         Wenhu Zhou, Runjhun Saran, Jinsong Ding and Juewen Liu*, "Two Completely Different Mechanisms for Highly Specific Na+ Recognition by DNAzymes", ChemBioChem, 2017, 18, 1828-1835

8.         Wenhu Zhou, Runjhun Saran and Juewen Liu*, "Metal Sensing by DNA", Chemical Reviews, 2017, 117, 8272–8325

9.         Wenhu Zhou, Runjhun Saran, Po-Jung Jimmy Huang, Jinsong Ding and Juewen Liu*, "An Exceptionally Selective DNA Cooperatively Binding Two Ca2+ Ions", ChemBioChem, 2017, 18, 518-522.

10.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Theranostic DNAzymes", Theranostics, 2017, 7, 1010-1025

11.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "2-Aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver", Biosensors & Bioelectronics, 2017, 87, 171-177

12.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A highly specific sodium aptamer probed by 2-aminopurine for robust Na+ sensing", Nucleic Acids Research, 2016, 44, 10377-10385

13.     Wenhu Zhou, Tianmeng Yu, Mahsa Vazin, Jinsong Ding and Juewen Liu*, "Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis", Inorganic Chemistry, 2016, 55, 8193–8200

14.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence", ChemBioChem, 2016, 17, 1563–1570

15.     Wenhu Zhou, Mahsa Vazin, Tianmeng Yu Jinsong Ding and Juewen Liu*, "In Vitro Selection of Chromium-Dependent DNAzymes for Sensing Cr(III) and Cr(VI)", Chemistry, a European Journal, 2016, 22, 9835-9840

16.     Wenhu Zhou, Yupei Zhang, Jinsong Ding* and Juewen Liu*, "In Vitro Selection in Serum: RNA-Cleaving DNAzymes for Measuring Ca2+ and Mg2+", ACS Sensors, 2016, 1, 600-606

17.     Wenhu Zhou, Jinsong Ding and Juewen Liu*, "An Efficient Lanthanide-Dependent DNAzyme Cleaving 2’-5’ Linked RNA", ChemBioChem, 2016, 17, 890-894

18.     Wenhu Zhou, Runjhun Saran, Qingyun Chen, Jinsong Ding and Juewen Liu*, "A New Na+-Dependent RNA-Cleaving DNAzyme with over 1000-fold Rate Acceleration by Ethanol", ChemBioChem, 2016, 17, 159-163

19.     Wenhu Zhou, Yupei Zhang, Po-Jung Jimmy Huang, Jinsong Ding, and Juewen Liu*, "A DNAzyme requiring two different metal ions at two distinct sites", Nucleic Acids Research, 2016, 44, 354-363

20.     Wenhu Zhou, Jinsong Ding* and Juewen Liu*, "A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold", Chemical Communications, 2015, 51, 12084-12087

21.     Wenhu Zhou, Qingyun Chen, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "DNAzyme Hybridization, Cleavage, Degradation and Sensing in Undiluted Human Blood Serum", Analytical Chemistry, 2015, 87, 4001–4007

22.     Wenhu Zhou, Feng Wang, Jinsong Ding* and Juewen Liu*, "Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles", ACS Applied Materials & Interfaces, 2014, 6, 14795-14800

23.     Wenhu Zhou, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "Aptamer-based biosensors for biomedical diagnostics", Analyst, 2014, 139, 2627-2640

24.     Wenhu Zhou, Yanbin Zhou, Jianping Wu, Zhenbao Liu, Huanzhe Zhao, Juewen Liu*, and Jinsong Ding*. "Aptamer-nanoparticle bioconjugates enhance Intracellular delivery of vinorelbine to breast cancer cells", Journal of Drug Targeting, 2014, 22(1): 57-66

25.     Wenhu Zhou, Shiying He, Yijun Yang, Dan Jian, Xiang Chen*, and Jinsong Ding*," Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma”, Drug development and industrial pharmacy, 2015, 41 (7), 1109-1119

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