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博士生导师
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丁劲松教授
2017-05-22 09:20   审核人:

 

丁劲松,19722月生

教授,博导

药剂学系主任

电话(073182650250  

传真(073182650489  

Email:dingjs0221@163.com  

教育经历:

1990-1994年,华西医科大学药学院(现四川大学华西药学院)药学专业,获学士学位。1997-2000年,华西医科大学药学院(现四川大学华西药学院)药剂学专业,获硕士学位。2003-2007年,中南大学药学院药理学专业(生物药剂学方向),获博士学位。

工作经历:

1994-1995年,湖南医科大学湘雅医院(现中南大学湘雅医院),进修。1995-1997年,湖南医科大学附三院(现中南大学湘雅三医院)。2000-2004年,中南大学湘雅二医院。2004-至今,中南大学药学院药剂学系。

课题组网站:http://dingjs.com/

研究领域:

应用基础研究:核酸适配体介导药物及诊断试剂纳米粒靶向传递系统研究;应用研究:缓控释制剂、药物经皮肤传递系统的研究,药物新剂型的研究与开发;研究生规模:在读研究生约18人。每年招收硕士生2-4名,博士生1-2名。

主要业绩与社会兼职:

主持国家重大新药创制科技专项课题、国家自然科学基金课题、省科技厅科技计划重点项目、市重点科技项目等科研项目8项,完成国家新药药学研究(CMC)和临床研究(BE/PK)项目共60余项,申请专利7项。近5年发表论文80余篇,参编专著2部、主编(副)/参编教材7部。

中国药学会药剂专业委员会委员;中国药学会纳米药物专业委员会委员;国家卫计委3D打印医学应用专家委员会委员;湖南省创新药物制剂研究重点实验室(培育)学术委员会主任;湖南省药学会药剂专业委员会副主任委员;湖南省制剂优化与早期临床评价工程技术研究中心副主任;湖南省药物安全评价协会理事;湖南省新药审评专家库成员;湖南省药用辅料战略联盟副秘书长。《解放军医学杂志》、《中国医院药学杂志》、《中南药学》、《中国药剂学杂志》、《儿科药学杂志》等杂志(通讯)编委。

在研课题:

1.国家十二五重大专项,2012ZX09103101 -051,基于Procaspase-3激活的1.1类抗肺癌新药SM-1的成药性研究,主持。

2.国家十二五重大专项,2012ZX09201201-001),感冒灵颗粒组方合理性研究,子任务主持。

3.国家自然科学基金,编号:81573774,药物相互作用对共包载盐霉素和siRNA纳米给药系统抗肿瘤效应的影响及其分子机制研究,主持。

4.深圳市重大产业技术攻关计划,编号:SW201110152,难溶型药物胃肠道缓释递药系统产业化成型与评价的关键技术研究,主持

代表论文:

[30] Li J, Mao J, Ding J*, et al. Surface spermidine functionalized PEGylatedpoly(lactide-co-glycolide) nanoparticles for tumor-targeted drug delivery[J]. RSC Advances, 2017,7, 22954-22963.

[29] Zhou W, Ding J, Liu J*. TheranosticDNAzymes[J]. Theranostics, 2017, 7(4): 1010.

[28] Zhou W, Ding J, Liu J*. 2-aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver[J]. Biosensors and Bioelectronics, 2017, 87: 171-177.

[27] Zhou W, Saran R, Huang P J J,Ding J, Liu J*. An Exceptionally Selective DNA Cooperatively Binding Two Ca2+ Ions[J]. ChemBioChem, 2017, 18(6): 518-522.

[26] Chen Y, Sun M, Ding J*, et al. SM-1, a novel PAC-1 derivative, activates procaspase-3 and causes cancer cell apoptosis[J]. Cancer chemotherapy and pharmacology, 2016, 78(3): 643-654.

[25] Zhou W, Ding J, Liu J*. A highly specific sodium aptamer probed by 2-aminopurine for robust Na+ sensing[J]. Nucleic Acids Research, 2016,44(21):10377-10385.

[24] Zhou W, Yu T, Vazin M, Ding J, Liu J*. Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis[J]. Inorganic chemistry, 2016, 55(16): 8193-8200.

[23] Zhou W, Saran R, Chen Q, Ding J, Liu J*. A New Na+Dependent RNACleaving DNAzyme with over 1000fold Rate Acceleration by Ethanol[J]. ChemBioChem, 2016, 17(2): 159-163.

[22] Zhou W, Ding J, Liu J*. An Efficient LanthanideDependent DNAzyme Cleaving 2′–5′‐Linked RNA[J]. ChemBioChem, 2016, 17(10): 890-894.

[21] Zhou W, Zhang Y, Huang P J J, Ding J, Liu J*. A DNAzyme requiring two different metal ions at two distinct sites[J]. Nucleic acids research, 2016, 44(1): 354-363.

[20] Zhou W, Zhang Y, Ding J*, Liu J*. In Vitro Selection in Serum: RNA-Cleaving DNAzymes for Measuring Ca2+ and Mg2+[J]. ACS Sensors, 2016, 1(5): 600-606.

[19] Zhou W, Ding J, Liu J*. A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence[J]. ChemBioChem, 2016, 17(16): 1563-1570.

[18] Zhou W, Vazin M, Yu T,Ding J, Liu J*. In Vitro Selection of ChromiumDependent DNAzymes for Sensing Chromium (III) and Chromium (VI)[J]. Chemistry-A European Journal, 2016, 22(28): 9835-9840.

[17] Qiu C, Wei W, Sun J, Zhang H, Ding J, et al. Systemic delivery of siRNA by hyaluronan-functionalized calcium phosphate nanoparticles for tumor-targeted therapy[J]. Nanoscale, 2016, 8(26): 13033-13044.

[16] Zhang Y, Tian D, Huang Y, Ding J*,et al. Pharmacokinetic evaluation of Shenfu Injection in beagle dogs after intravenous drip administration[J]. ActaPharmaceuticaSinica B, 2016, 6(6): 584-592.

[15] Zhou W, Ding J*, Liu J*. A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold[J]. Chemical Communications, 2015, 51(60): 12084-12087.

[14] Zhou W, Chen Q, Huang P J J, Ding J*,Liu J*. DNAzyme hybridization, cleavage, degradation, and sensing in undiluted human blood serum[J]. Analytical chemistry, 2015, 87(7): 4001-4007.

[13] Liu Z, Zhao H, He L, Yao Y, Zhou Y, Ding J*,Liu J*. Aptamer density dependent cellular uptake of lipid-capped polymer nanoparticles for polyvalent targeted delivery of vinorelbine to cancer cells[J]. RSC Advances, 2015, 5(22): 16931-16939.

[12] Tang J, Liu Z, Zhang Y, Li D, Ding J*,Xuehua Jiang*. Fluorofenidone-loaded PLGA microspheres for targeted treatment of paraquat-induced acute lung injury in rats[J]. RSC Advances, 2015, 5(38): 30153-30159.

[11] Zhou W, He S, Yang Y, Jian D, Chen X, Ding J*. Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma[J]. Drug development and industrial pharmacy, 2015, 41(7): 1109-1119.

[10] Liu Z, Chen S, Liu B, Wu J, Zhou Y, He L, Ding J*,Liu J*. Intracellular detection of ATP using an aptamer beacon covalently linked to graphene oxide resisting nonspecific probe displacement[J]. Analytical chemistry, 2014, 86(24): 12229-12235.

[9]     Zhou W, Wang F, Ding J*,Liu J*. Tandem phosphorothioate modifications for DNA adsorption strength and polarity control on gold nanoparticles[J]. ACS applied materials & interfaces, 2014, 6(17): 14795-14800.

[8]     Liu Z, Liu B, Ding J, Liu J*. Fluorescent sensors using DNA-functionalized graphene oxide[J]. Analytical and bioanalytical chemistry, 2014, 406(27): 6885-6902.

[7]     Zhou W, Huang P J J, Ding J*,Liu J*. Aptamer-based biosensors for biomedical diagnostics[J]. Analyst, 2014, 139(11): 2627-2640.

[6]     Zhou W, Zhou Y, Wu J, Liu Z, Zhao H, Ding J*,Liu J*.Aptamer-nanoparticle bioconjugates enhance intracellular delivery of vinorelbine to breast cancer cells[J]. Journal of drug targeting, 2014, 22(1): 57-66.

[5]     Xu S,Peng J,Li Y, He L, Chen F, Zhang J,DingJ*, et al. Pharmacokinetic comparisons of rutaecarpine and evodiamine after oral administration of Wu-Chu-Yu extracts with different purities to rats[J]. Journal of ethnopharmacology, 2012, 139(2): 395-400.

[4]     Chen F, Li S, Li D, Ding J*. Transdermal behaviors comparisons among Evodiarutaecarpa extracts with different purity of evodiamine and rutaecarpine and the effect of topical formulation in vivo[J]. Fitoterapia, 2012, 83(5): 954-960.

[3]     Tang J, Tan Z R, Zhou Y B, Ding J*. High-performance liquid chromatography-tandem mass spectrometry for the determination of trospium chloride in human plasma and its application in a bioequivalence study[J]. Analytical Letters, 2011, 44(4): 607-616.

[2]     Ding J, Gao R, Li D, Peng J, Ran L, Li Y*. Solid dispersion of rutaecarpine improved its antihypertensive effect in spontaneously hypertensive rats[J]. Biopharmaceutics & drug disposition, 2008, 29(9): 495-500.

[1]     Ding J*, Zhou Y, He J, Song J, Tan Z. Quantification of teprenone in human plasma by HPLC coupled to mass spectrometry: Application to a bioequivalence study[J]. Chromatographia, 2007, 65(9-10): 533-538.

2017-05-22 更新

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