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博士生导师
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彭军 教授
2018-09-05 08:02   审核人:

 

联系方式

通讯地址:长沙市湘雅路110号,中南大学药理学系,

邮编:410078

电话:0731-82355078

电子邮件:junpeng@csu.edu.cn

个人简介

彭军, 男,19688月出生,研究员、二级教授,博士生导师, 中南大学“升华学者计划”特聘教授。1991年毕业于湖南医科大学, 1997年获湖南医科大学生物化学硕士学位, 2002年获中南大学药理学博士学位。 2002-2007年在美国华盛顿州立大学从事博士后工作。现为中南大学湘雅药学院药理学系主任,兼任《中国动脉硬化杂志》编委、国际动脉硬化学会中国分会理事、中国动脉硬化专业委员会委员、中国药理学学会心血管专业委员会委员、中药与天然药物药理专业委员会委员、湖南省药学会理事、湖南省生理学会常务理事、湖南省药理学会秘书长等职。

主要方向为内源性活性物质在心脑血管疾病中作用和机制及药物防治,已CirculationProc. Natl. Acad.Sci. USACirc ResBasic Res CardiolClin Sci等国际权威和知名期刊发表论文90 余篇,参编教材2部(国家级药学类规划教材《药理学》)和专5部(《心血管药理学》《药理实验方法学》等)。先后获得全国优秀博士学位论文奖、湖南省青年科技奖、中华医学科技奖、湖南省科学技术进步奖等多项奖励。先后主持国家自然科学基金5 (包括重大研究计划1) 以及美国心脏学会博士后基金、全国优博专项基金、教育部博士点基金(博导类)和湖南省自然科学基金重点项目各1项;参与国家“973”计划项目、国家自然科学基金重点项目美国NIH 项目等多项;2008 年入选湖南省普通高校学科带头人培养对象,2010 年入选湖南省“121人才工程。

代表作:

  1. Zhang YZ, Wang L, Zhang JJ, Xiong XM,      Zhang D, Tang XM, Luo XJ, Ma QL, Peng J*(彭军,通讯作者). Vascular peroxide 1 promotes      ox-LDL-induced programmed necrosis in endothelial cells through a      mechanism involving β-catenin signaling. Atherosclerosis. 2018; 274:128-138.      

  2. Zhang YS, Tang LJ, Tu H, Wang SJ, Liu B,      Zhang XJ, Li NS, Luo XJ, Peng J*(彭军,通讯作者). Fasudil ameliorates the      ischemia/reperfusion oxidative injury in rat hearts through suppression of      myosin regulatory light chain/NADPH oxidase 2 pathway. Eur J Pharmacol.      2018;822:1-12.

  3. Zhang JJ, Zhang YZ, Peng JJ, Li NS, Xiong      XM, Ma QL, Luo XJ, Liu B, Peng J*(彭军,通讯作者). Atorvastatin exerts inhibitory      effect on endothelial senescence in hyperlipidemic rats through a      mechanism involving down-regulation of miR-21-5p/203a-3p. Mech Ageing Dev.      2018; 169:10-18.

  4. Tian J, Guo S, Chen H, Peng JJ, Jia MM,      Li NS, Zhang XJ, Yang J, Luo XJ, Peng J*(彭军,通讯作者). Combination of Emricasan with Ponatinib Synergistically      Reduces Ischemia/Reperfusion Injury in Rat Brain Through Simultaneous      Prevention of Apoptosis and Necroptosis. Transl Stroke Res. 2018; 9(4):      382-392.

  5. Peng JJ, Liu B, Xu JY, Peng J*(彭军,通讯作者), Luo XJ*. NADPH oxidase: its potential role in      promotion of pulmonary arterial hypertension. Naunyn      Schmiedebergs Arch Pharmacol. 2017; 390(4): 331-338

  6. Li TB, Zhang JJ, Liu B, Luo XJ, Ma      QL*, Peng J*(彭军,通讯作者). Dysfunction      of endothelial progenitor cells in hyperlipidemic rats involves the      increase of NADPH oxidase-derived reactive oxygen species production. Can J Physiol Pharmacol. 2017; 95(5):474-480.

  7. Liu B, Ren KD, Peng JJ, Li T, Luo XJ, Fan      C, Yang JF, Peng J*(彭军,通讯作者). Suppression of NADPH oxidase      attenuates hypoxia-induced dysfunctions of endothelial progenitor cells. Biochem      Biophys Res Commun. 2017; 482(4):1080-1087.

  8. Li JH, Ju GX, Jiang JL, Li NS, Peng      J*(彭军,通讯作者), Luo XJ*. Lipoic acid protects      gastric mucosa from ethanol-induced injury in rat through a mechanism      involving aldehyde dehydrogenase 2 activation. Alcohol. 2016; 56:21-28.      doi: 10.1016/j.alcohol.2016.10.004.

9.     Yang ZB, Li TB, Zhang Z, Ren KD, Zheng ZF, Peng J, Luo XJ. The Diagnostic Value of Circulating Brain-specific MicroRNAs for Ischemic Stroke. Intern Med. 2016;55(10):1279-86.

  1. Peng J*(彭军,并列第一), Ren KD*,      Yang J, Luo XJ. Mitochondrial E3 ubiquitin ligase 1: A key enzyme in      regulation of mitochondrial dynamics and functions. Mitochondrion. 2016;      28:49-53.

  2. Li TB, Zhang JJ, Liu B, Liu WQ, Wu Y,      Xiong XM, Luo XJ, Ma QL, Peng J*(彭军,通讯作者). Involvement of NADPH oxidases      and non-muscle myosin light chain in senescence of endothelial progenitor      cells in hyperlipidemia. Naunyn Schmiedebergs Arch Pharmacol. 2016; 389(3):289-302.

  3. Wu Y, Zhang JJ, Li TB, Liu WQ, Li LS, Luo      XJ, Jiang JL, Ma QL, Yang ZC, Peng J*(彭军,通讯作者). Phosphorylation of Nonmuscle      Myosin Light Chain Promotes Endothelial Injury in Hyperlipidemic Rats      Through a Mechanism Involving Downregulation of Dimethylarginine      Dimethylaminohydrolase 2. J Cardiovasc Pharmacol Ther. 2016; 21(6):536-548.

  4. Liu B, Li T, Peng JJ, Zhang JJ, Liu WQ,      Luo XJ, Ma QL, Gong ZC, Peng J*(彭军,通讯作者). Non-muscle myosin light chain      promotes endothelial progenitor cells senescence and dysfunction in      pulmonary hypertensive rats through up-regulation of NADPH oxidase. Eur J Pharmacol. 2016;775:67-77.

  5. Yang ZB,      Luo XJ, Ren KD, Peng JJ, Tan B,      Liu B, Lou Z, Xiong XM, Zhang XJ,      Ren X, Peng J*(彭军,通讯作者). Beneficial effect of magnesium      lithospermate B on cerebral ischemia-reperfusion injury in rats involves      the regulation of miR-107/glutamate transporter 1 pathway. Eur J Pharmacol.      2015; 766: 91-98.

  6. Zhang HF, Li TB, Liu B, Lou Z, Zhang JJ,      Peng JJ, Zhang XJ, Ma QL, Peng J*, Luo XJ. Inhibition of myosin      light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat      brain following cerebral ischemia/reperfusion. Naunyn Schmiedebergs Arch      Pharmacol. 2015; 388(9): 953-632.

  7. Zhang YS, Liu B, Luo XJ, Li TB, Zhang JJ,      Peng JJ, Zhang XJ, Ma QL, Hu CP, Li YJ, Peng J*(彭军,通讯作者), Li Q. Nuclear cardiac myosin      light chain 2 modulates NADPH oxidase 2 expression in myocardium: a novel function      beyond muscle contraction. Basic Res Cardiol. 2015;110(4):38

  8. Zhang YS, Liu B, Luo XJ, Zhang JJ, Li NS,      Ma QL, Jiang JL, Li YJ, Li Q, Peng J*(彭军,通讯作者). A novel function of nuclear      nonmuscle myosin regulatory light chain in promotion of xanthine oxidase      transcription after myocardial ischemia/reperfusion. Free Radic Biol Med.      2015; 83:115-128.

  9. Peng J(彭军), Liu B, Ma QL, Luo XJ. Dysfunctional endothelial progenitor      cells in cardiovascular diseases: role of NADPH oxidase. J Cardiovasc      Pharmacol. 2015; 65(1):80-7.

  10. Luo XJ, Liu B, Ma QL, Peng J*(彭军,通讯作者). Mitochondrial      AldehydDehydrogenase, a Potential Drug Target for Protection of Heart and      Brain from Ischemia/Reperfusion Injury. Curr Drug Targets. 2014;15(10): 948-55.

  11. Yang ZB, Zhang Z, Li TB, Lou Z, Li SY,      Yang H, Yang J, Luo XJ, Peng J*(彭军,通讯作者). Up-regulation of brain-enriched      miR-107 promotes excitatory neurotoxicity through down-regulation of      glutamate transporter-1 expression following ischaemic stroke. Clin Sci      (Lond). 2014;127(12):679-89.

  12. Ma QL, Zhang GG, Peng J*(彭军,通讯作者). Vascular Peroxidase 1: a Novel      Enzyme in Promoting Oxidative Stress in Cardiovascular System. Trends      Cardiovasc Med, 2013, 23: 179-183.

  13. Zhang YS, He L, Liu B, Li NS, Luo XJ, Hu      CP, Ma QL, Zhang GG, Li YJ, Peng J*(彭军,通讯作者). A novel pathway of NADPH      oxidase/vascular peroxidase 1 in mediating oxidative injury following ischemia – reperfusion. Basic Res Cardiol, 2012, 107(3):266.

  14. He L, Liu B, Dai Z, Zhang HF, Zhang YS,      Luo XJ, Ma QL, Peng J* (彭军,通讯作者). Alpha lipoic acid protects heart against myocardial      ischemia-reperfusion injury through a mechanism involving aldehyde      dehydrogenase 2 activation. Eur J Pharmacol. 2012; 678(1-3):32-8.

  15. Peng J(彭军), Raddatz K, Molkentin JD, Yiming Wu, Granzier H, Gotthardt M.      Cardiac hypertrophy and reduced contractility in hearts deficient in titin      kinase region. Circulation, 2007, 115(6):743-51.

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